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Št. zadetkov: 2
Nature-inspired substituted 3-(imidazol-2-yl) morpholines targeting human topoisomerase IIα
Barbara Herlah, Matej Janežič, Iza Ogris, Simona Golič Grdadolnik, Katja Kološa, Sonja Žabkar, Bojana Žegura, Andrej Perdih
Izvirni znanstveni članek
Oznake: topoisomerase II;catalytic inhibitors;chemotherapy;DNA damage;cancer;
The molecular nanomachine, human DNA topoisomerase IIα, plays a crucial role in replication, transcription, and recombination by catalyzing topological changes in the DNA, rendering it an optimal target for cancer chemotherapy. Current clinical topoisomerase II poisons often cause secondary tumors a ...
Leto: 2024 Vir: Kemijski inštitut (KI)
New class of Hsp90 C-terminal domain inhibitors with anti-tumor properties against triple-negative breast cancer
Živa Zajec, Jaka Dernovšek, Jernej Cingl, Iza Ogris, Marius Gedgaudas, Asta Zubrienė, Ana Mitrović, Simona Golič Grdadolnik, Martina Gobec, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: analize;zaviralci;fenili;rak dojk;
Triple-negative breast cancer (TNBC) remains a treatment challenge and requires innovative therapies. Hsp90, crucial for the stability of numerous oncogenic proteins, has emerged as a promising therapeutic target. In this study, we present the optimization of the Hsp90 C-terminal domain (CTD) inhibi ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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