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Št. zadetkov: 3
Mechanistic insight into the dynamics of Mur ligase through a comprehensive timescale-specific approach
Iza Ogris, Barbara Zupančič, Izidor Sosič, Franci Merzel, Simona Golič Grdadolnik
Izvirni znanstveni članek
Oznake: muramil ligaze;sinteza bakterijskih peptidoglikanov;MurD ligaza;NMR v raztopini;
Muramyl ligases are multidomain enzymes involved in intracellular steps of bacterial peptidoglycan synthesis and are considered promising targets for the development of new antibacterial agents. Among them, Mur ligase D (MurD) has been most widely used for structure-based design, but success has bee ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Nature-inspired substituted 3-(imidazol-2-yl) morpholines targeting human topoisomerase IIα
Barbara Herlah, Matej Janežič, Iza Ogris, Simona Golič Grdadolnik, Katja Kološa, Sonja Žabkar, Bojana Žegura, Andrej Perdih
Izvirni znanstveni članek
Oznake: topoisomerase II;catalytic inhibitors;chemotherapy;DNA damage;cancer;
The molecular nanomachine, human DNA topoisomerase IIα, plays a crucial role in replication, transcription, and recombination by catalyzing topological changes in the DNA, rendering it an optimal target for cancer chemotherapy. Current clinical topoisomerase II poisons often cause secondary tumors a ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
New class of Hsp90 C-terminal domain inhibitors with anti-tumor properties against triple-negative breast cancer
Živa Zajec, Jaka Dernovšek, Jernej Cingl, Iza Ogris, Marius Gedgaudas, Asta Zubrienė, Ana Mitrović, Simona Golič Grdadolnik, Martina Gobec, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: analize;zaviralci;fenili;rak dojk;
Triple-negative breast cancer (TNBC) remains a treatment challenge and requires innovative therapies. Hsp90, crucial for the stability of numerous oncogenic proteins, has emerged as a promising therapeutic target. In this study, we present the optimization of the Hsp90 C-terminal domain (CTD) inhibi ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 3
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