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Št. zadetkov: 2
Spermidine supplementation influences mitochondrial number and morphology in the heart of aged mice
Jil Messerer, Christoph Wrede, Julia Schipke, Christina Brandenberger, Mahmoud Abdellatif, Tobias Eisenberg, Frank Madeo, Simon Sedej, Christian Mühlfeld
Izvirni znanstveni članek
Oznake: aging;focused ion beam scanning electron microscopy;mitochondria;spermidine;stereology;
Aging is associated with cardiac hypertrophy and progressive decline in heart function. One of the hallmarks of cellular aging is the dysfunction of mitochondria. These organelles occupy around 1/4 to 1/3 of the cardiomyocyte volume. During cardiac aging, the removal of defective or dysfunctional mi ...
Leto: 2023 Vir: Medicinska fakulteta (UM MF)
Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca2+ cycling
Senka Ljubojevic-Holzer, Simon Kraler, Nataša Djalinac, Mahmoud Abdellatif, Julia Voglhuber, Julia Schipke, Marlene Schmidt, Katharina-Maria Kling, Greta Therese Franke, Viktoria Herbst, Simon Sedej
Izvirni znanstveni članek
Oznake: autophagy;beta-adrenergic signalling;calcium;cardiomyocytes;mitochondria;
Aims: Autophagy protects against the development of cardiac hypertrophy and failure. While aberrant Ca2+ handling promotes myocardial remodelling and contributes to contractile dysfunction, the role of autophagy in maintaining Ca2+ homeostasis remains elusive. Here, we examined whether Atg5 deficien ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Št. zadetkov: 2
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