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Št. zadetkov: 4
Karakterizacija znotrajceličnega prometa in signaliziranja s herpesvirusnimi s proteinom G sklopljenimi receptorji
Maša Mavri, Valentina Kubale Dvojmoč, Katja Spiess
Doktorska disertacija
Oznake: molekularna biologija;celična membran;človeški herpesvirus 4;prašičji herpesvirus;receptor;sklopljen z G-proteinom;protein transport – fiziologija;prenos signalov;endocitoza;kaveolin;klatrin;dynamin;
Cilj disertacije sta opredelitev in primerjava molekularnih in bioloških lastnosti ortologov BILF1, kodiranih v treh prašičjih limfotropnih herpesvirusih (PLHV1-3) in humanem virusu Epstein-Barr (EBV). Proučevali smo lokalizacijo, konstitutivno internalizacijo, konstitutivno aktivnost in imunoregula ...
Leto: 2023 Vir: Veterinarska fakulteta (UL VF)
Methods for studying endocytotic pathways of herpesvirus encoded G protein-coupled receptors
Maša Mavri, Katja Spiess, Mette Marie Rosenklide, Catrin Rutland, Milka Vrecl, Valentina Kubale
Pregledni znanstveni članek
Oznake: endocytosis;G-protein coupled receptors;herpesvirus;methods;Herpesviridae;
Endocytosis is a fundamental process involved in trafficking of various extracellular and transmembrane molecules from the cell surface to its interior. This enables cells to communicate and respond to external environments, maintain cellular homeostasis, and transduce signals. G protein-coupled rec ...
Leto: 2020 Vir: Veterinarska fakulteta (UL VF)
Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis
Maša Mavri, Sanja Glisic, Milan Sencanski, Milka Vrecl, Mette Marie Rosenklide, Katja Spiess, Valentina Kubale
Izvirni znanstveni članek
Oznake: Herpesvirus 4;human;Dynamins;Caveolins;beta-Arrestins;
Background: The viral G protein-coupled receptor (vGPCR) BILF1 encoded by the Epstein-Barr virus (EBV) is an oncogene and immunoevasin and can downregulate MHC-I molecules at the surface of infected cells. MHC-I downregulation, which presumably occurs through co-internalization with EBV-BILF1, is pr ...
Leto: 2023 Vir: Veterinarska fakulteta (UL VF)
Epstein-Barr virus-encoded BILF1 orthologues from porcine lymphotropic herpesviruses display common molecular functionality
Maša Mavri, Valentina Kubale, Daniel P. Depledge, Jianmin Zuo, Christene A. Huang, Judith Breuer, Milka Vrecl, Michael A. Jarvis, Eva Jarc, Toni Petan, Bernhard Ehlers, Mette Marie Rosenklide, Katja Spiess
Izvirni znanstveni članek
Oznake: Epstein-Barr virus;porcine lymphotropic herpesviruses (PLHV);BILF1;G protein signaling;MHC class I;drug target;post-transplant lymphoproliferative disease;in-vivo model;
Infection of immunosuppressed transplant patients with the human γ-herpesvirus Epstein-Barr virus (EBV) is associated with post-transplant lymphoproliferative disease (PTLD), an often fatal complication. Immunosuppressed miniature pigs infected with γ-herpesvirus porcine lymphotropic herpesvirus 1 ( ...
Leto: 2022 Vir: Veterinarska fakulteta (UL VF)
Št. zadetkov: 4
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