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Št. zadetkov: 12
Fragment-sized and bidentate (immuno)proteasome inhibitors derived from cysteine and threonine targeting warheads
Levente Kollár, Martina Gobec, Matic Proj, Lara Smrdel, Damijan Knez, Tímea Imre, Ágnes Gömöry, László Petri, Stanislav Gobec, Izidor Sosič
Izvirni znanstveni članek
Oznake: immunoproteasome;benzoxazole-2-carbonitriles;bidentate covalent inhibitors;fragments;non-covalent recognition;
Constitutive- and immunoproteasomes are part of the ubiquitin–proteasome system (UPS), which is responsible for the protein homeostasis. Selective inhibition of the immunoproteasome offers opportunities for the treatment of numerous diseases, including inflammation, autoimmune diseases, and hematolo ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead
Katarina Grabrijan, Martina Hrast, Matic Proj, Ana Dolšak, Irena Zdovc, Tímea Imre, László Petri, Péter Ábrányi-Balogh, György Keserü M., Stanislav Gobec
Izvirni znanstveni članek
Oznake: antibakterijska sredstva;UDP-N-acetilglukozamin enolpiruvil transferaza;tiolna reaktivnost;antibacterial agents;UDP-N-Acetylglucosamine enolpyruvyl transferase;thiol reactivity;
MurA (UDP-N-acetylglucosamine enolpyruvyl transferase) catalyzes the first committed step in the cytoplasmic part of peptidoglycan biosynthesis and is a validated target enzyme for antibacterial drug discovery; the inhibitor fosfomycin has been used clinically for decades. Like fosfomycin, most MurA ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Next-generation heterocyclic electrophiles as small-molecule covalent MurA inhibitors
Péter Ábrányi-Balogh, Aaron Keeley, György G. Ferenczy, László Petri, Tímea Imre, Katarina Grabrijan, Martina Hrast, Damijan Knez, Janez Ilaš, Stanislav Gobec, György Keserü M.
Izvirni znanstveni članek
Oznake: kovalentni inhibitor;heterociklični elektrofili;označevanje cisteina;kvaternizacija;MurA;covalent inhibitor;heterocyclic electrophiles;cysteine labelling;quaternization;
Heterocyclic electrophiles as small covalent fragments showed promising inhibitory activity on the antibacterial target MurA (UDP-N-acetylglucosamine 1-carboxyvinyltransferase, EC:2.5.1.7). Here, we report the second generation of heterocyclic electrophiles: the quaternized analogue of the heterocyc ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Bromo-cyclobutenaminones as new covalent UDP-N-acetylglucosamine enolpyruvyl transferase (murA) inhibitors
David J. Hamilton, Péter Ábrányi-Balogh, Aaron Keeley, László Petri, Martina Hrast, Tímea Imre, Maikel Wijtmans, Stanislav Gobec, Iwan J. P. de Esch, György Keserü M.
Izvirni znanstveni članek
Oznake: covalent inhibitor;MurA;cyclobutenaminone;antibacterial;irreversible;
Drug discovery programs against the antibacterial target UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) have already resulted in covalent inhibitors having small three- and five-membered heterocyclic rings. In the current study, the reactivity of four-membered rings was carefully modulated t ...
Leto: 2020 Vir: Fakulteta za farmacijo (UL FFA)
Vegetation of the dolines in Mecsek mountains (South Hungary) in relation to the local plant communities
Zoltán Bátori, János Csiky, László Erdős, László Kőrmőczi, Tamás Morschhauser, Péter Tőrők
Izvirni znanstveni članek
Oznake: dolines;vegetation;diagnostic species;habitat conditions;ecological indicator values;
Leto: 2009 Vir: dLib.si Digitalna knjižnica Slovenije
Vegetation of the Dolines in Mecsek Mountains (South Hungary) in relation to the Local Plant Communities
Zoltán Bátori, János Csiky, László Erdős, Tamás Morschhauser, Péter Tőrők, László Kőrmőczi
Ni določena
Oznake:
This paper deals with the forest vegetation of the lower part of the dolines in Mecsek Mts. (South Hungary). In order to char-acterize this vegetation type, samples were compared to the 6 plant communities occurring in the neighbourhood of the dolines. Considering the vegetation texture and species ...
Leto: 2009 Vir: ZRC SAZU
Health professionals' knowledge of probiotics
Sabina Fijan, Anita Frauwallner, László Varga, Tomaž Langerholc, Irena Rogelj, Mateja Lorber, Peter Lewis, Petra Povalej
Izvirni znanstveni članek
Oznake: probiotics;knowledge;health professionals;
The objective of this study was to survey health professionals to investigate their knowledge of probiotics. An online survey was conducted to gather data on the knowledge of health professionals. The online survey was distributed via email and social media platforms using snowball sampling. A total ...
Leto: 2019 Vir: Digitalna knjižnica Univerze v Mariboru (DKUM)
Vegetation of the Dolines in Mecsek Mountains (South Hungary) in relation to the Local Plant Communities
Zoltan Batori, Laszlo Erdős, Tamás Morschhauser, Péter Török, László Körmöczi
Izvirni znanstveni članek
Oznake:
This paper deals with the forest vegetation of the lower part of the dolines in Mecsek Mts. (South Hungary). In order to char-acterize this vegetation type, samples were compared to the 6 plant communities occurring in the neighbourhood of the dolines. Considering the vegetation texture and species ...
Leto: 2009 Vir: ZRC SAZU
Analysis of drip water in an urban karst cave beneath the Hungarian capital (Budapest)
Katalin Fehér, József Kovács, László Márkus, Edit Borbás, Péter Tanos, István Gábor Hatvani
Ni določena
Oznake: cave drip water; hydrochemistry; karst; Pál-völgyi Cave System; time series analysis; urban pollution
Our geological heritage is increasingly threatened by anthropogenic activity. This is especially true of the Pál-völgyi Cave System beneath Budapest. It is among the 150 longest and at the same time most endangered cave systems in the world. The aims of the study were (i) to set up a monitoring syst ...
Leto: 2016 Vir: ZRC SAZU
Analysis of drip water in an urban karst cave beneath the Hungarian capital (Budapest)
Katalin Fehér, József Kovács, László Márkus, Edit Borbás, Péter Tanos, István Gábor Hatvani
Izvirni znanstveni članek
Oznake: cave drip water;hydrochemistry;karst;Pál-völgyi Cave System;time series analysis;urban pollution
Our geological heritage is increasingly threatened by anthropogenic activity. This is especially true of the Pál-völgyi Cave System beneath Budapest. It is among the 150 longest and at the same time most endangered cave systems in the world. The aims of the study were (i) to set up a monitoring syst ...
Leto: 2016 Vir: ZRC SAZU
Št. zadetkov: 12
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