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Št. zadetkov: 6
Vloga vzgojitelja pri hospitaliziranem predšolskem otroku
Maša Peterlin, Danijela Lahe
Diplomsko delo
Oznake: diplomska dela;predšolski otrok;hospitalizacija;bolezen;pravice otrok;vloga staršev in vzgojiteljev;
Diplomsko delo sestavljata teoretični in empirični del. Osnovni cilj je prikazati pomen vzgojitelja ob prihodu bolnega otroka na oddelek bolnišnice in vlogo vzgojitelja pri hospitaliziranem predšolskem otroku in ugotoviti pravice hospitaliziranega otroka v bolnišnici. Pri teoretičnem delu je opredel ...
Leto: 2020 Vir: Pedagoška fakulteta (UM PEF)
Analiza čustvene inteligentnosti in delovne storilnosti v izbranem podjetju
Maša Štravs, Judita Peterlin
Magistrsko delo
Oznake: uporaba človeških zmogljivosti;kadri;čustvena inteligentnost;delovna uspešnost;produktivnost;analiza;
Analiza čustvene inteligentnosti in delovne storilnosti v izbranem podjetju
Leto: 2017 Vir: Ekonomska fakulteta (UL EF)
Discovery of K V 1.3 ion channel inhibitors
Špela Gubič, Louise Antonia Hendrickx, Žan Toplak, Maša Sterle, Steve Peigneur, Tihomir Tomašić, Luis A. Pardo, Jan Tytgat, Anamarija Zega, Lucija Peterlin-Mašič
Pregledni znanstveni članek
Oznake: KV1.3 channel;design of KV1.3 inhibitors;mitochondrial KV1.3;peptide inhibitors;small-molecule inhibitors;
The KV1.3 voltage gated potassium ion channel is involved in many physiological processes both at the plasma membrane and in the mitochondria, chiefly in the immune and nervous systems. Therapeutic targeting KV1.3 with specific peptides and small molecule inhibitors shows great potential for treatin ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Discovery and Hit-to-Lead Optimization of Benzothiazole scaffold-based DNA gyrase inhibitors with potent activity against Acinetobacter baumannii and Pseudomonas aeruginosa
Andrej Emanuel Cotman, Martina Durcik, Davide Benedetto Tiz, Federica Fulgheri, Maša Sterle, Štefan Možina, Žiga Skok, Nace Zidar, Anamarija Zega, Janez Ilaš, Lucija Peterlin-Mašič, Tihomir Tomašić, Danijel Kikelj
Izvirni znanstveni članek
Oznake: antibacterial activity;bacteria;genetics;inhibitors;solubility;
We have developed compounds with a promising activity against Acinetobacter baumannii and Pseudomonas aeruginosa, which are both on the WHO priority list of antibiotic-resistant bacteria. Starting from DNA gyrase inhibitor 1, we identified compound 27, featuring a 10-fold improved aqueous solubility ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
New N-phenylpyrrolamide inhibitors of DNA gyrase with improved antibacterial activity
Andrej Emanuel Cotman, Federica Fulgheri, Martina Piga, Peter Peršolja, Davide Benedetto Tiz, Žiga Skok, Martina Durcik, Maša Sterle, Jaka Dernovšek, Anamarija Zega, Lucija Peterlin-Mašič, Janez Ilaš, Tihomir Tomašić, Danijel Kikelj, Nace Zidar
Izvirni znanstveni članek
Oznake: N-fenilpirolamidni inhibitorji;bakterijske DNA giraze;sinteza spojin;antibakterijsko delovanje;
This study presents the discovery of a new series of N-phenylpyrrolamide inhibitors of bacterial DNA gyrase with improved antibacterial activity. The most potent inhibitors had low nanomolar IC50 values against Escherichia coli DNA gyrase (IC50; 2–20 nM) and E. coli topoisomerase IV (22i, IC50 = 143 ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Exploring the 5-substituted 2-aminobenzothiazole-based DNA gyrase B inhibitors active against ESKAPE pathogens
Maša Sterle, Martina Durcik, Clare E. M. Stevenson, Sara R. Henderson, Petra Eva Szili, Marton Czikkely, David M. Lawson, Danijel Kikelj, Nace Zidar, Lucija Peterlin-Mašič, Janez Ilaš, Tihomir Tomašić, Andrej Emanuel Cotman, Anamarija Zega
Izvirni znanstveni članek
Oznake: inhibitorji;organske kisline;proteini;bacteria;genetics;inhibitors;organic acids;peptides;proteins;
We present a new series of 2-aminobenzothiazole-based DNA gyrase B inhibitors with promising activity against ESKAPE bacterial pathogens. Based on the binding information extracted from the cocrystal structure of DNA gyrase B inhibitor A, in complex with Escherichia coli GyrB24, we expanded the chem ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 6
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