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Št. zadetkov: 6
Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart
Mahmoud Abdellatif, Frank Madeo, Guido Kroemer, Simon Sedej
Kratki znanstveni prispevek
Oznake: heart failure;IGF1R;PI3K;human;insulin signaling;longevity;mitochondrial dysfunction;mouse;
Although attenuated IGF1R (insulin-like growth factor 1 receptor) signaling has long been viewed to promote longevity in model organisms, adverse effects on the heart have been the subject of major concern. We observed that IGF1R is overexpressed in cardiac tissues from patients with end-stage non-i ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Targeting cardiovascular risk factors through dietary adaptations and caloric restriction mimetics
Julia Voglhuber, Senka Ljubojevic-Holzer, Mahmoud Abdellatif, Simon Sedej
Pregledni znanstveni članek
Oznake: autophagy;caloric restriction;caloric restriction mimetics;cardiovascular risk factors;dietary regimens;hypertension;intermittent fasting;obesity;
he average human life expectancy continues to rise globally and so does the prevalence and absolute burden of cardiovascular disease. Dietary restriction promotes longevity and improves various cardiovascular risk factors, including hypertension, obesity, diabetes mellitus, and metabolic syndrome. H ...
Leto: 2021 Vir: Medicinska fakulteta (UM MF)
Spermidine supplementation influences mitochondrial number and morphology in the heart of aged mice
Jil Messerer, Christoph Wrede, Julia Schipke, Christina Brandenberger, Mahmoud Abdellatif, Tobias Eisenberg, Frank Madeo, Simon Sedej, Christian Mühlfeld
Izvirni znanstveni članek
Oznake: aging;focused ion beam scanning electron microscopy;mitochondria;spermidine;stereology;
Aging is associated with cardiac hypertrophy and progressive decline in heart function. One of the hallmarks of cellular aging is the dysfunction of mitochondria. These organelles occupy around 1/4 to 1/3 of the cardiomyocyte volume. During cardiac aging, the removal of defective or dysfunctional mi ...
Leto: 2023 Vir: Medicinska fakulteta (UM MF)
Fine-tuning cardiac insulin-like growth factor 1 receptor signaling to promote health and longevity
Mahmoud Abdellatif, Viktoria Herbst, Alexander Martin Heberle, Alina Humnig, Tobias Pendl, Sylvère Durand, Giulia Cerrato, Sebastian J Hofer, Moydul Islam, Julia Voglhuber, Simon Sedej
Izvirni znanstveni članek
Oznake: aging;autophagy;cardiomyopathies;insulin-like growth factor 1;mitochondria;mouse;phosphatidylinositol 3-kinases;
Background: The insulin-like growth factor 1 (IGF1) pathway is a key regulator of cellular metabolism and aging. Although its inhibition promotes longevity across species, the effect of attenuated IGF1 signaling on cardiac aging remains controversial. Methods: We performed a lifelong study to assess ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Nicotinamide for the treatment of heart failure with preserved ejection fraction
Mahmoud Abdellatif, Viktoria Herbst, Franziska Koser, Sylvère Durand, Rui Adão, Francisco Vasques-Nóvoa, Johanna K Freundt, Julia Voglhuber, Maria Rosaria Pricolo, Michael Kasa, Simon Sedej
Izvirni znanstveni članek
Oznake: heart failure;hypertension;niacinamide;metabolic syndrome;
Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent and intractable form of cardiac decompensation commonly associated with diastolic dysfunction. Here, we show that diastolic dysfunction in patients with HFpEF is associated with a cardiac deficit in nicotinamide adenine din ...
Leto: 2021 Vir: Medicinska fakulteta (UM MF)
Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca2+ cycling
Senka Ljubojevic-Holzer, Simon Kraler, Nataša Djalinac, Mahmoud Abdellatif, Julia Voglhuber, Julia Schipke, Marlene Schmidt, Katharina-Maria Kling, Greta Therese Franke, Viktoria Herbst, Simon Sedej
Izvirni znanstveni članek
Oznake: autophagy;beta-adrenergic signalling;calcium;cardiomyocytes;mitochondria;
Aims: Autophagy protects against the development of cardiac hypertrophy and failure. While aberrant Ca2+ handling promotes myocardial remodelling and contributes to contractile dysfunction, the role of autophagy in maintaining Ca2+ homeostasis remains elusive. Here, we examined whether Atg5 deficien ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Št. zadetkov: 6
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