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Št. zadetkov: 5
Hitri algoritmi za drsečo spektralno analizo
Marko Zdovc, Peter Planinšič, Bojan Grčar
Diplomsko delo
Oznake: spektralna analiza;DFT;FFT;drseča FFT;Goertzel algoritem;transformatorji;MatLab;
Hitri algoritmi za drsečo spektralno analizo : diplomska naloga visokošolskega strokovnega študijskega programa
Leto: 2001 Vir: Fakulteta za elektrotehniko, računalništvo in informatiko (UM FERI)
Structurally optimized potent dual-targeting NBTI antibacterials with an enhanced bifurcated halogen-bonding propensity
Maja Kokot, Matjaž Weiss, Irena Zdovc, Martina Hrast, Marko Anderluh, Nikola Minovski
Izvirni znanstveni članek
Oznake: NBTIs;DNA gyrase;topoisomerase IV;bifurcated halogen bonds;dual targeting;
We designed and synthesized an optimized library of novel bacterial topoisomerase inhibitors with p-halogenated phenyl right-hand side fragments and significantly enhanced and balanced dual-targeted DNA gyrase and topoisomerase IV activities of Staphylococcus aureus and Escherichia coli. By increasi ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Exploring alternative pathways to target bacterial type II topoisomerases using NBTI antibacterials: beyond halogen-bonding interactions
Maja Kokot, Doroteja Novak, Irena Zdovc, Marko Anderluh, Martina Hrast, Nikola Minovski
Izvirni znanstveni članek
Oznake: DNA gyrase;topoisomerase IV;antibacterial;NBTIs;halogen-bonding interactions;hydrogen-bonding interactions;van der Waals interactions;
Novel bacterial topoisomerase inhibitors (NBTIs) are a new class of antibacterial agents that target bacterial type II topoisomerases (DNA gyrase and topoisomerase IV). Our recently disclosed crystal structure of an NBTI ligand in complex with DNA gyrase and DNA revealed that the halogen atom in the ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacy
Maja Kokot, Matjaž Weiss, Irena Zdovc, L. Šenerović, Natasa Radakovic, Marko Anderluh, Nikola Minovski, Martina Hrast
Izvirni znanstveni članek
Oznake: DNA giraza;topoizomeraza IV;antibakterijska zdravila;inhibicija;učinkovitost in vivo;NBTIs;DNA gyrase;Topoisomerase IV;antibacterials;MRSA;hERG inhibition;in vivo efficacy;
Novel bacterial topoisomerase inhibitors (NBTIs) are new promising antimicrobials for the treatment of multidrug-resistant bacterial infections. In recent years, many new NBTIs have been discovered, however most of them struggle with the same issue - the balance between antibacterial activity and hE ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
ǂA ǂfine-tuned lipophilicity/hydrophilicity ratio governs antibacterial potency and selectivity of bifurcated halogen bond-forming NBTIs
Anja Kolarič, Maja Kokot, Martina Hrast, Matjaž Weiss, Irena Zdovc, Jurij Trontelj, Simon Žakelj, Marko Anderluh, Nikola Minovski
Izvirni znanstveni članek
Oznake: antibacterials;drug discovery;DNA gyrase inhibitors;topoisomerase IV inhibitors;intercalators;novel bacterial topoisomerase inhibitors;antibakterijska sredstva;raziskave zdravil;zaviralci DNA giraz;zaviralci topoizomeraze IV;interkalator;novi zaviralci bakterijske topoizomeraze;
Herein, we report the design of a focused library of novel bacterial topoisomerase inhibitors (NBTIs) based on innovative mainly monocyclic right-hand side fragments active against DNA gyrase and Topo IV. They exhibit a very potent and wide range of antibacterial activity, even against some of the m ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 5
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