Št. zadetkov: 99
Pregledni znanstveni članek
Oznake:
cholinesterases;enzyme inhibition;organoruthenium complex;neuromuscular junction;mouse;
Cholinesterase (ChE) inhibitors are crucial therapeutic agents for the symptomatic treatment of certain chronic neurodegenerative diseases linked to functional disorders of the cholinergic system. Significant research efforts have been made to develop novel derivatives of classical ChE inhibitors an ...
Leto:
2024
Vir:
Veterinarska fakulteta (UL VF)
Pregledni znanstveni članek
Oznake:
Alzheimerjeva bolezen;patofiziologija;etiologija;terapija z zdravili;
Alzheimerjeva bolezen je kronična progresivna nevrodegenerativna bolezen, za katero oboleva vse večje število ljudi po
vsem svetu. Je najpogostejši vzrok za demenco (pri 50–80 % vseh primerov) in obenem tudi najhujša oblika demence, za
katero so značilne kognitivne in vedenjske motnje pri ljudeh, ...
Leto:
2022
Vir:
Veterinarska fakulteta (UL VF)
Izvirni znanstveni članek
Oznake:
organoruthenium(II) complex;acetylcholinesterase;butyrylcholinesterase;mouse neuromuscular system;ruthenium;Alzheimer disease;neurodegenerative diseases;
Enzyme butyrylcholinesterase (BChE) shows increased activity in some brain regions after progression of Alzheimer’s disease and is therefore one of the therapeutic targets for symptomatic treatment of this neurodegenerative disorder. The organoruthenium(II) complex [(n6-pcymene) Ru(II)(1-hydroxy-3-m ...
Leto:
2023
Vir:
Veterinarska fakulteta (UL VF)
Izvirni znanstveni članek
Oznake:
kačji strup;encimska aktivnost;snake venom;ammodytoxin;secreted phospholipase A2;anzymatic activity;cytochrome c oxidase;ß-neurotoxicity;
Presynaptic- or β-neurotoxicity of secreted phospholipases A2 (sPLA2) is a complex process. For full expression of β-neurotoxicity, the enzymatic activity of the toxin is essential. However, it has been shown that not all toxic effects of a β-neurotoxin depend on its enzymatic activity, for example, ...
Leto:
2024
Vir:
Veterinarska fakulteta (UL VF)
Izvirni znanstveni članek
Oznake:
organoruthenium nitrophenanthroline complex;acetylcholinesterase;butyrylcholinesterase;glutathione S-transferase;mouse neuromuscular system;ruthenium;muscle relaxation;physiology;glutathione transferase;
In addition to antibacterial and antitumor effects, synthetic ruthenium complexes have been reported to inhibit several medicinally important enzymes, including acetylcholinesterase (AChE). They may also interact with muscle-type nicotinic acetylcholine receptors (nAChRs) and thus affect the neuromu ...
Leto:
2020
Vir:
Veterinarska fakulteta (UL VF)
Izvirni znanstveni članek
Oznake:
astrocytes;cyclic cyanobacterial peptides;cytoskeletal organization;Ser/Thr phosphatases;systemic toxicity;
The systemic toxicity of cyclic peptides produced by cyanobacteria (CCPs) is not yet completely understood. Apart from the most known damages to the liver and kidneys, symptoms of their neurotoxicity have also been reported. Hepatotoxic CCPs, like microcystins, as well as non-hepatotoxic anabaenopep ...
Leto:
2024
Vir:
Veterinarska fakulteta (UL VF)
Izvirni znanstveni članek
Oznake:
astrociti;ciklični cianobakterijski peptidi;citoskeletna organizacija;Ser/Thr fosfataze;sistemska toksičnost;cianobakterije;astrocytes;cyclic cyanobacterial peptides;cytoskeletal organization;Ser/Thr phosphatases;systemic toxicity;cyanobacteria;
The systemic toxicity of cyclic peptides produced by cyanobacteria (CCPs) is not yet completely understood. Apart from the most known damages to the liver and kidneys, symptoms of their neurotoxicity have also been reported. Hepatotoxic CCPs, like microcystins, as well as non-hepatotoxic anabaenopep ...
Leto:
2024
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
cholinesterase;enzyme inhibition;glutathione S-transferase;organoruthenium complex;pyrithione;β-diketone;carbonyl;glutathione transferase;
Cholinesterases (ChEs) show increased activities in patients with Alzheimer’s disease, and remain one of the main therapeutic targets for treatment of this neurodegenerative disorder. A library of organoruthenium(II) complexes was prepared to investigate the influence of their structural elements on ...
Leto:
2021
Vir:
Veterinarska fakulteta (UL VF)
Izvirni znanstveni članek
Oznake:
stranski učinki;egerolizini;Apis mellifera;bioinsekticidi;erilizin A;protein z domeno MACPF;netarčni organizmi;bukov ostrigar;Porcellio scaber;toksičnost;adverse effects;aegerolysins;bioinsecticides;erylysin A;MACPF protein;non-target organisms;oyster mushroom;toxicity;
Aegerolysin proteins ostreolysin A6 (OlyA6), pleurotolysin A2 (PlyA2) and erylysin A (EryA) produced by the mushroom genus Pleurotus bind strongly to an invertebrate-specific membrane sphingolipid, and together with a protein partner pleurotolysin B (PlyB), form transmembrane pore complexes. This po ...
Leto:
2021
Vir:
Biotehniška fakulteta (UL BF)
Izvirni znanstveni članek
Oznake:
organometallic ruthenium complexes;nicotinic acetylcholine receptors;nicotinic antagonists;electrophysiology;two-electrode voltage-clamp technique;
Nicotinic acetylcholine receptors (nAChRs) are expressed in excitable and non-excitable cells of the organism. Extensive studies suggest that nAChR ligands have therapeutic potential, notably for neurological and psychiatric disorders. Organometallic ruthenium complexes are known to inhibit several ...
Leto:
2024
Vir:
Veterinarska fakulteta (UL VF)