Št. zadetkov: 16
Pregledni znanstveni članek
Oznake:
glioblastom;možganski rak;nekodirani genom;biološki označevalec;prognoza;glioblastoma;brain cancer;noncoding genome;biomarker;prognosis;
Glioblastoma is the most aggressive and lethal primary brain malignancy, with an average patient survival from diagnosis of 14 months. Glioblastoma also usually progresses as a more invasive phenotype after initial treatment. A major step forward in our understanding of the nature of glioblastoma wa ...
Leto:
2020
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
glioblastoma;extracellular vesicles;nanoscience;
Owing to the advancement of technology combined with our deeper knowledge of human nature and diseases, we are able to move towards precision medicine, where patients are treated at the individual level in concordance with their genetic profiles. Lately, the integration of nanoparticles in biotechno ...
Leto:
2020
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
glioblastoma;heterogeneity;non-animal models;treatmet predicition;
Glioblastoma is an extremely lethal cancer characterized by great heterogeneity at different molecular and cellular levels. As a result, treatment options have moved far from systemic and universal therapies toward targeted treatments and personalized medicine. However, for successful translation fr ...
Leto:
2023
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
citoskelet;glioblastom;označevalci;cytoskeleton;glioblastoma;biomarkers;
Glioblastoma, the most common primary brain malignancy, is an exceptionally fatal cancer. Lack of suitable biomarkers and efficient treatment largely contribute to the therapy failure. Cytoskeletal proteins are crucial proteins in glioblastoma pathogenesis and can potentially serve as biomarkers and ...
Leto:
2021
Vir:
Medicinska fakulteta (UL MF)
Doktorska disertacija
Oznake:
Glioblastoma multiforme;biooznačevalec;nano-protitelesa;Onkologija;Disertacije;Glioblastom;Biomolekularni označevalci;Tarčna zdravila;Proteomika;Nano-protitelesa;
Glioblastom multiforme (GBM) je gliom, tumor osrednjega živčnega sistema, najpogostejša oblika možganskega tumorja, za katerim zboli 3-5 bolnikov na 100.000 ljudi. Povprečni čas preživetja bolnikov z GBM je od časa diagnosticiranja 12 do 18 mesecev, ob kombinirani postoperativni terapiji z uporabo t ...
Leto:
2018
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
oligonukleotid;oligonukleotidni začetnik;informacijski sistem;vodenje;računalniška podpora;spletna aplikacija;oligonucleotide;primer;information system;management;computational support;web application;
With the increasing number of molecular biology techniques, large numbers of oligonucleotides are frequently involved in individual research projects. Thus, a dedicated electronic oligonucleotide management system is expected to provide several benefits such as increased oligonucleotide traceability ...
Leto:
2021
Vir:
Fakulteta za računalništvo in informatiko (UL FRI)
Izvirni znanstveni članek
Oznake:
glioblastoma;malignancy;FREM2;SPRY1;TCGA;
World Health Organization grade IV diffuse gliomas, known as glioblastomas, are the most common malignant brain tumors, and they show poor prognosis. Multimodal treatment of surgery followed by radiation and chemotherapy is not sufficient to increase patient survival, which is 12 to 18 months after ...
Leto:
2019
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
glioblastoma;stem cells;nanobodies;cell migration;citotoxicity;vimentin;DPYSL2;NAP1L1;TUFM;
Background: Glioblastoma is a particularly common and very aggressive primary brain tumour. One of the main causes of therapy failure is the presence of glioblastoma stem cells that are resistant to chemotherapy and radiotherapy, and that have the potential to form new tumours. This study focuses on ...
Leto:
2020
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
glioblastom;23/5000 matične celice glioblastoma;biomarkerji;glioblastoma;glioblastoma stem cells;biomarkers;
Glioblastoma (GB) is the most aggressive brain malignancy. Although some potential glioblastoma biomarkers have already been identified, there is a lack of cell membrane-bound biomarkers capable of distinguishing brain tissue from glioblastoma and/or glioblastoma stem cells (GSC), which are responsi ...
Leto:
2018
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
gliom;glioblastom;napoved preživetja;glioma;glioblastoma;survival prognosis;
Gliomas are the most common malignant brain tumors with high mortality rates. Recently we showed that the FREM2 gene has a role in glioblastoma progression. Here we reconstructed the FREM2 molecular pathway using the human interactome model. We assessed the biomarker capacity of FREM2 expression and ...
Leto:
2021
Vir:
Medicinska fakulteta (UL MF)