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Št. zadetkov: 2
Stereoselective activity of 1-propargyl-4-styrylpiperidine-like analogues that can discriminate between monoamine oxidase isoforms A and B
Damijan Knez, Natalia Colettis, Luca G. Iacovino, Matej Sova, Anja Pišlar, Janez Konc, Samo Lešnik, Josefina Higgs, Fabiola Kamecki, Irene Mangialavori, Ana Dolšak, Simon Žakelj, Jurij Trontelj, Janko Kos, Claudia Binda, Nora Marder Mariel, Stanislav Gobec
Izvirni znanstveni članek
Oznake: razvoj zdravil;toksikologija zdravil;monoamin oksidaze;
The resurgence of interest in monoamine oxidases (MAOs) has been fueled by recent correlations of this enzymatic activity with cardiovascular, neurological, and oncological disorders. This has promoted increased research into selective MAO-A and MAO-B inhibitors. Here, we shed light on how selective ...
Leto: 2020 Vir: Fakulteta za farmacijo (UL FFA)
Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities—The case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice
Carolina Marcucci, Marina Rademacher, Fabiola Kamecki, Valentina Pastore, Hernán Gerónimo Bach, Rafael Alejandro Ricco, Marcelo Luis Wagner, Damijan Knez, Stanislav Gobec, Natalia Colettis, Mariel Marder
Izvirni znanstveni članek
Oznake: acetilholinesteraza;agregacija β-amiloida;monoaminooksidaza;spomin;Alzheimer’s disease;medicinal plant;acetylcholinesterase;antioxidant;β-amyloid aggregation;monoamine oxidase;memory;antidepressant;
Alzheimer’s disease (AD) is a neurodegenerative disorder whose pathophysiology includes the abnormal accumulation of proteins (e.g., β-amyloid), oxidative stress, and alterations in neurotransmitter levels, mainly acetylcholine. Here we present a comparative study of the effect of extracts obtained ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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