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Št. zadetkov: 3
Lipidation of NOD2 agonists with adamantane and stearoyl moieties differentially regulates their In vivo adjuvant activity
Samo Guzelj, Marcela Šišić, Špela Bizjak, Leo Frkanec, Ruža Frkanec, Žiga Jakopin
Izvirni znanstveni članek
Oznake: agonisti NOD2;adjuvans za cepivo;adamantan;imunopotenciatorji;desmuramilpeptidi;NOD2 agonist;vaccine adjuvant;adamantane;immunopotentiators;desmuramylpeptides;
NOD2 is an innate immune receptor that constitutes an important target for the development of small molecule immunopotentiators with great potential to be used as vaccine adjuvants. We report here the results of an in vivo study of the adjuvant properties of a desmuramylpeptide NOD2 agonist SG29 and ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Covalently conjugated NOD2/TLR7 agonists are potent and versatile immune potentiators
Samo Guzelj, Matjaž Weiss, Bram Slütter, Ruža Frkanec, Žiga Jakopin
Izvirni znanstveni članek
Oznake: immunostimulatory activity;vaccines;immune responses;pattern recognition receptors;synthesis of NOD2 agonist;Toll-like receptor 7;
The success of vaccination with subunit vaccines often relies on the careful choice of adjuvants. There is great interest in developing new adjuvants that can elicit a cellular immune response. Here, we address this challenge by taking advantage of the synergistic cross-talk between two pattern reco ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Structural fine-tuning of desmuramylpeptide NOD2 agonists defines their in vivo adjuvant activity
Samo Guzelj, Sanja Vrbek, Martina Gobec, Stane Pajk, Veronika Klančič, Bram Slütter, Ruža Frkanec, Adela Štimac, Primož Šket, Janez Plavec, Irena Mlinarič-Raščan, Žiga Jakopin
Izvirni znanstveni članek
Oznake: reakcijski produkti;reaction products;peptides and proteins;cells;organic compounds;toxicity;
We report on the design, synthesis, and biological evaluation of a series of nucleotide-binding oligomerization-domain-containing protein 2 (NOD2) desmuramylpeptide agonists with improved in vitro and in vivo adjuvant properties. We identified two promising compounds: 68, a potent nanomolar in vitro ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 3
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