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Št. zadetkov: 2
Targeting cardiovascular risk factors through dietary adaptations and caloric restriction mimetics
Julia Voglhuber, Senka Ljubojevic-Holzer, Mahmoud Abdellatif, Simon Sedej
Pregledni znanstveni članek
Oznake: autophagy;caloric restriction;caloric restriction mimetics;cardiovascular risk factors;dietary regimens;hypertension;intermittent fasting;obesity;
he average human life expectancy continues to rise globally and so does the prevalence and absolute burden of cardiovascular disease. Dietary restriction promotes longevity and improves various cardiovascular risk factors, including hypertension, obesity, diabetes mellitus, and metabolic syndrome. H ...
Leto: 2021 Vir: Medicinska fakulteta (UM MF)
Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca2+ cycling
Senka Ljubojevic-Holzer, Simon Kraler, Nataša Djalinac, Mahmoud Abdellatif, Julia Voglhuber, Julia Schipke, Marlene Schmidt, Katharina-Maria Kling, Greta Therese Franke, Viktoria Herbst, Simon Sedej
Izvirni znanstveni članek
Oznake: autophagy;beta-adrenergic signalling;calcium;cardiomyocytes;mitochondria;
Aims: Autophagy protects against the development of cardiac hypertrophy and failure. While aberrant Ca2+ handling promotes myocardial remodelling and contributes to contractile dysfunction, the role of autophagy in maintaining Ca2+ homeostasis remains elusive. Here, we examined whether Atg5 deficien ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Št. zadetkov: 2
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