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Izvirni znanstveni članek
Oznake: aging;autophagy;cardiomyopathies;insulin-like growth factor 1;mitochondria;mouse;phosphatidylinositol 3-kinases;
Background: The insulin-like growth factor 1 (IGF1) pathway is a key regulator of cellular metabolism and aging. Although its inhibition promotes longevity across species, the effect of attenuated IGF1 signaling on cardiac aging remains controversial. Methods: We performed a lifelong study to assess ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Izvirni znanstveni članek
Oznake: heart failure;hypertension;niacinamide;metabolic syndrome;
Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent and intractable form of cardiac decompensation commonly associated with diastolic dysfunction. Here, we show that diastolic dysfunction in patients with HFpEF is associated with a cardiac deficit in nicotinamide adenine din ...
Leto: 2021 Vir: Medicinska fakulteta (UM MF)
Št. zadetkov: 2
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