Iskalni niz:
išči po
išči po
išči po
išči po
Vrsta gradiva:
Jezik:
Št. zadetkov: 6
Proučevanje vloge estrogenov pri neodzivnosti celične linije raka jajčnikov na karboplatin
Tinkara Kreft, Tea Lanišnik-Rižner, Damjana Drobne
Magistrsko delo
Oznake: rak jajčnikov;estrogeni;kemorezistenca;OVCAR-3;karboplatin;
Serozni rak jajčnikov visokega gradusa (HGSOC) je najbolj smrtonosna oblika raka jajčnikov predvsem zaradi pozne postavitve diagnoze in razvoja na kemoterapevtike odporne oblike bolezni. Natančna vloga estrogenov v patogenezi HGSOC še ni jasna, lahko pa ti spodbujajo celično proliferacijo preko rece ...
Leto: 2023 Vir: Biotehniška fakulteta (UL BF)
Uporaba tehnik preurejanja genoma za razvoj učinkovitejših celičnih terapij CAR-T
Tinkara Kreft, Jernej Ogorevc, Jernej Ogorevc, Mojca Narat, Jana Murovec
Diplomsko delo
Oznake: CAR-T;preurejanje genoma;imunoterapija;rak;CRISPR/Cas;celična terapija;
Terapija z modificiranimi limfociti T (CAR-T) je ena najsodobnejših oblik imunoterapije za zdravljenja raka. Temelji na genetsko spremenjenih, pacientu avtolognih celicah T, ki na svoji površini izražajo himerni antigenski receptor (ang. chimeric antigen receptor ali CAR). Ta je sposoben prepoznati ...
Leto: 2020 Vir: Biotehniška fakulteta (UL BF)
ǂThe ǂimportance of sex dimorphism in liver metabolism and progressive liver diseases
Eva Kočar, Kaja Blagotinšek Cokan, Tinkara Kreft, Tadeja Režen, Damjana Rozman, Damjana Rozman
Pregledni znanstveni članek
Oznake: animal models;fibrosis;HCC;liver;MASH;MASLD;sexual dimorphism;
The liver is a central metabolic organ with pronounced sex-specific differences shaped by sex hormones, sex chromosome-linked gene expression, ageing, and circadian rhythm. These factors influence disease susceptibility, progression, and treatment response, with notable differences between females a ...
Leto: 2026 Vir: Medicinska fakulteta (UL MF)
Targeting estrogen metabolism in high-grade serous ovarian cancer shows promise to overcome platinum resistance
Nika Marolt, Renata Pavlič, Tinkara Kreft, Marija Gjorgoska, Tea Lanišnik-Rižner, Tea Lanišnik-Rižner
Izvirni znanstveni članek
Oznake: high-grade serous ovarian cancer;estrogen metabolisem;prognostic biomarkers;therapeutic targets;transcriptomic analysis;
The high mortality rate due to chemoresistance in patients with high-grade ovarian cancer (HGSOC) emphasizes the urgent need to determine optimal treatment strategies for advanced and recurrent cases. Our study investigates the interplay between estrogens and chemoresistance in HGSOC and shows clear ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
Knockouts of CYP51A1, DHCR24, or SC5D from cholesterol synthesis reveal pathways modulated by sterol intermediates
Cene Skubic, Hana Trček, Petra Nassib, Tinkara Kreft, Andrew Walakira, Katka Pohar, Sara Petek, Tadeja Režen, Alojz Ihan, Damjana Rozman, Damjana Rozman
Izvirni znanstveni članek
Oznake: cholesterol synthesis;sterol intermediates;CYP51A1;DHCR24;SC5D;
Sterols from cholesterol synthesis are crucial for cholesterol production, but also have individual roles difficult to assess in vivo due to essentiality of cholesterol. We developed HepG2 cell models with knockouts (KOs) for three enzymes of cholesterol synthesis, each accumulating specific sterols ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
Hepatic management of toxic sterols after acute deletion of Cyp51 from cholesterol synthesis
Tinkara Kreft, Kaja Blagotinšek Cokan, Cene Skubic, Tadeja Režen, Martina Perše, Karmen Wechtersbach, Nika Kojc, Jera Jeruc, Željko Debeljak, Marija Heffer, Madlen Matz-Soja, Damjana Rozman, Damjana Rozman
Izvirni znanstveni članek
Oznake: CYP51;cholesterol metabolism;crystals;cytochrome P450;lanosterol 14α-demethylase;lipid droplets;liver;mouse model;sterol;
Lanosterol 14α-demethylase (CYP51), a key enzyme in cholesterol synthesis, is essential for normal liver function. Reduced CYP51 activity leads to metabolism-associated liver disease and ultimately hepatocellular carcinoma, yet the hepatocellular processes most affected and their crosstalk with othe ...
Leto: 2026 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 6
Ključne besede:
Leto izdaje:
Avtorji:
Repozitorij:
Tipologija:
Jezik: