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Št. zadetkov: 6
Determinante poklicnega odločanja v obdobju mladostništva
Tjaša Urbančič, Katarina Babnik
Diplomsko delo
Oznake: poklicno odločanje;mladostništvo;teorije poklicnega odločanja;determinante poklicnega odločanja;
Determinante poklicnega odločanja v obdobju mladostništva
Leto: 2013 Vir: Univerza na Primorskem (UP)
Discovery of new Hsp90–Cdc37 protein–protein interaction inhibitors
Jaka Dernovšek, Nina Gradišek, Živa Zajec, Dunja Urbančič, Jernej Cingl, Tjaša Goričan, Simona Golič Grdadolnik, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: protein 90 (Hsp90);inhibition of protein–protein interaction;virtual screening;ligand-based pharmacophore models;
The interaction between heat shock protein 90 (Hsp90) and Hsp90 co-chaperone cell-division cycle 37 (Cdc37) is crucial for the folding and maturation of several oncogenic proteins, particularly protein kinases. This makes the inhibition of this protein–protein interaction (PPI) an interesting target ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
First dual inhibitors of human topoisomerase IIα and Hsp90 C-terminal domain inhibit the growth of Ewing sarcoma in vitro and in vivo
Jaka Dernovšek, Dunja Urbančič, Živa Zajec, Caterina Sturtzel, Tjaša Goričan, Simona Golič Grdadolnik, Žiga Skok, Janez Ilaš, Nace Zidar, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: cancer;Ewing sarcoma;Hsp90;inhibitor;topoisomerase IIα;zebrafish;
Heat shock protein 90 (Hsp90) and topoisomerase IIα (TopoIIα) are members of the GHKL protein superfamily, both with clinically validated roles as anticancer drug targets. We report the discovery of the first class of dual inhibitors targeting the ATP-binding site of TopoIIα and the C-terminal domai ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Hiding in plain sight
Jaka Dernovšek, Tjaša Goričan, Marius Gedgaudas, Živa Zajec, Dunja Urbančič, Ana Jug, Žiga Skok, Simona Golič Grdadolnik, Janez Ilaš, Nace Zidar, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: cancer;Hsp90;isoform selectivity;topoisomerase II;
Due to their impact on several oncogenic client proteins, the Hsp90 family of chaperones has been widely studied for the development of potential anticancer agents. Although several Hsp90 inhibitors have entered clinical trials, most were unsuccessful because they induced a heat shock response (HSR) ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Exploration and optimisation of structure-activity relationships of new triazole-based C-terminal Hsp90 inhibitors towards in vivo anticancer potency
Jaka Dernovšek, Živa Zajec, Goran Poje, Dunja Urbančič, Tjaša Goričan, Simona Golič Grdadolnik, Irena Mlinarič-Raščan, Andrej Emanuel Cotman, Nace Zidar, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: cancer;Hsp90;inhibitor;Ewing sarcoma;zebrafish;
The development of new anticancer agents is one of the most urgent topics in drug discovery. Inhibition of molecular chaperone Hsp90 stands out as an approach that affects various oncogenic proteins in different types of cancer. These proteins rely on Hsp90 to obtain their functional structure, and ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Čist (hud) komplet za čisto čiste roke
Filip Bregar, Julija Brudar, Tjaša Erjavec, Anita Kermavner, Manca Kukovičič, Erika Mohorčič, Špela Muha, Nika Nardin, Eva Šefic, Ana Vlahovič, Zlata Grofelnik, Tanja Jereb, Katja Polajnar, Ines Sabol, Petra Černe Oven, Gregor Jereb, Stojan Kostanjevec, Andreja Kukec, Gregor Jereb, Petra Černe Oven, Julija Brudar, Mojca Jevšnik, Matej Urbančič, Jera Gregorc
Strokovna monografija
Oznake: umivanje rok;higiena;otroci;vzgojitelji;starši;
Umivanje rok je eden ključnih higienskih ukrepov, ki ga sicer dobro poznamo, a žal ne izvajamo dovolj natančno, predvsem pa ne vedno, ko je treba. Gre za preprost način fizičnega odstranjevanja umazanije in škodljivih mikroorganizmov, kar lahko prepreči prenos nevarnih okužb in pojav bolezni. Če skl ...
Leto: 2023 Vir: Zdravstvena fakulteta (UL ZF)
Št. zadetkov: 6
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