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Št. zadetkov: 9
Razvoj modela in orodja za izbiro ustreznega programa za napredno planiranje in razvrščanje proizvodnje
Tomaž Grabnar, Tomaž Hovelja
Diplomsko delo
Oznake: razvrščanje;planiranje;APS;proizvodnja;kriteriji;računalništvo;visokošolski strokovni študij;računalništvo in informatika;diplomske naloge;
Proizvodna podjetja danes potrebujejo napredno planiranje in razvrščanje proizvodnje, da lahko ostajajo konkurenčna. Odločitev, kateri program izbrati za ta namen, pa je prepuščena njim samim, saj na trgu ni orodja, ki bi jim pri tem sistematično pomagalo. Zato smo se odločili razviti orodje za izbi ...
Leto: 2014 Vir: Fakulteta za računalništvo in informatiko (UL FRI)
ǂThe ǂevolving role of microsampling in therapeutic drug monitoring of monoclonal antibodies in inflammatory diseases
Panagiotis-Dimitrios Mingas, Jurij Zdovc, Iztok Grabnar, Tomaž Vovk
Pregledni znanstveni članek
Oznake: microsampling;DBS;VAMS;mAbs;TDM;inflammatory diseases;
Monoclonal antibodies (mAbs) have been extensively developed over the past few years, for the treatment of various inflammatory diseases. They are large molecules characterized by complex pharmacokinetic and pharmacodynamic properties. Therapeutic drug monitoring (TDM) is routinely implemented in th ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Oxidative stress-related biomarkers as promising indicators of inflammatory bowel disease activity
Armando Tratenšek, Igor Locatelli, Iztok Grabnar, David Drobne, Tomaž Vovk
Izvirni znanstveni članek
Oznake: inflammatory bowel disease;ulcerative colitis;Crohn's disease;oxidative stress;biomarker;meta-analysis;
Oxidative stress is believed to play an important role in the pathogenesis of inflammatory bowel disease (IBD), specifically Crohn's disease (CD) and ulcerative colitis (UC). This meta-analysis aimed to identify and quantify the oxidative stress-related biomarkers in IBD and their associations with ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Potential drug-drug interactions among patients with schizophrenia spectrum disorders
Cvetka Bačar, Katja Nagode, Mitja Pišlar, Aleš Mrhar, Iztok Grabnar, Tomaž Vovk
Izvirni znanstveni članek
Oznake: možne interakcije med zdravili;abdominalni stent-graft;program medsebojnega delovanja zdravil;simptomi in znaki;dejavniki tveganja;potential drug—drug interactions;schizophrenia;antipsychotics;drug interaction program;symptoms and signs;risk factors;
Background and Objectives: Patients with schizophrenia are often exposed to polypharmacotherapy, which may lead to drug—drug interactions. The aim of the study was to investigate the prevalence of potential drug—drug interactions (pDDIs) in hospitalized patients with schizophrenia spectrum disorders ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
ǂAn ǂLC-MS/MS method for quantification of lamotrigine and its main metabolite in dried blood spots
Daniela Milosheska, Robert Roškar, Tomaž Vovk, Bogdan Lorber, Iztok Grabnar, Jurij Trontelj
Izvirni znanstveni članek
Oznake: posušena krvna lisa;lamotrigin;lamotrigin glukuronid;terapevtsko spremljanje zdravil;klinična validacija;učinek hematokrita;dried blood spot;lamotrigine;lamotrigine glucuronide;therapeutic drug monitoring;clinical validation;haematocrit effect;
Background: The antiepileptic drug lamotrigine (LTG) shows high pharmacokinetic variability due to genotype influence and concomitant use of glucuronidation inducers and inhibitors, both of which may be frequently taken by elderly patients. Our goal was to develop a reliable quantification method fo ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Febrile neutropenia in chemotherapy treated small-cell lung cancer patients
Renata Režonja, Iztok Grabnar, Tomaž Vovk, Aleš Mrhar, Viljem Kovač, Tanja Čufer
Izvirni znanstveni članek
Oznake: small cell lung cancer;platinum-etoposide chemotherapy;etoposide;febrile neutropenia;plasma drug concentration;
Chemotherapy with platinum agent and etoposide for small-cell lung cancer (SCLC) is supposed to be associated with intermediate risk (10-20%) of febrileneutropenia. Primary prophylaxis with granulocyte colonystimulating factors (G-CSFs) is not routinely recommended by the treatment guidelines. Howev ...
Leto: 2015 Vir: Repozitorij Univerze v Ljubljani (RUL)
Curriculum mapping of the master's program in pharmacy in Slovenia with the PHAR-QA competency framework
Tanja Stopar, Nejc Horvat, Mitja Kos, Aleš Obreza, Tomaž Vovk, Iztok Grabnar, Borut Božič
Izvirni znanstveni članek
Oznake: pharmacy education;Slovenian curriculum;pharmacy profession;
This article presents the results of mapping the Slovenian pharmacy curriculum to evaluate the adequacy of the recently developed and validated European Pharmacy Competences Framework (EPCF). The mapping was carried out and evaluated progressively by seven members of the teaching staff at the Univer ...
Leto: 2017 Vir: Fakulteta za farmacijo (UL FFA)
Farmakokinetika koencima Q10 pri športnih konjih kasačih in njegov pomen pri preprečevanju oksidativnega stresa pri vadbi
Sara Jagrič Munih, Silvestra Kobal, Tomaž Vovk, Modest Vengušt, Iztok Grabnar, Marko Volk, Peter Dovč
Doktorska disertacija
Oznake: veterinarstvo;športni konji;vadba;lipidna peroksidacija;kri;kemična analiza;prehrana;antioksidanti;koencim Q10;
Farmakokinetika koencima Q10 pri športnih konjih kasačih in njegov pomen pri preprečevanju oksidativnega stresa pri vadbi
Leto: 2012 Vir: Veterinarska fakulteta (UL VF)
Ustekinumab dosing individualization in Crohn's disease guided by a population pharmacokinetic-pharmacodynamic model
Jurij Zdovc, Jurij Hanžel, Tina Kurent, Nejc Sever, Matic Koželj, Nataša Smrekar, Gregor Novak, Borut Štabuc, Tomaž Vovk, Barbara Ostanek, David Drobne, Iztok Grabnar
Izvirni znanstveni članek
Oznake: vnetje črevesja;terapevtsko spremljanje zdravil;fekalni kalprotektin;ustekinumab;inflammatory bowel disease;fecal calprotectin;pharmacokinetics-pharmacodynamics;therapeutic drug monitoring;
Ustekinumab is a monoclonal antibody used in Crohn's disease (CD). Dose optimization in case of non-response and the role of pharmacokinetic-pharmacodynamic (PK-PD) monitoring remain unresolved dilemmas in clinical practice. We aimed to develop a population PK-PD model for ustekinumab in CD and simu ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 9
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