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Št. zadetkov: 8
Mathematical modelling of molecular transmembrane transport and changes of tissues' dielectric properties due to electroporation
Janja Dermol-Černe, Damijan Miklavčič, Gregor Serša
Doktorska disertacija
Oznake: elektroporacija;
Visokonapetostni električni pulzi povečajo prepustnost celične membrane (Tsong 1991; Weaver 1993; Kotnik et al. 2012) skozi pore (Abidor et al. 1979), ki nastanejo na tistih njenih delih, kjer vsiljena transmembranska napetost preseže kritično vrednost (Towhidi et al. 2008; Kotnik et al. 2010). E ...
Leto: 2018 Vir: Fakulteta za elektrotehniko (UL FE)
MATHEMATICAL MODELING OF MOLECULAR TRANSMEMBRANE TRANSPORT AND CHANGES OF TISSUES´ DIELECTRIC PROPERTIES DUE TO ELECTROPORATION
JANJA DERMOL-ČERNE, Damijan Miklavčič, Gregor Serša
Doktorska disertacija
Oznake: Electroporation;multiscale modeling;excitable cells;predictive models;electrochemotherapy;numerical modeling;irreversible electroporation;
Electroporation is a phenomenon, which occurs when short high voltage pulses are applied to cells and tissues resulting in a transient increase in membrane permeability or cell death, presumably due to pore formation. If cells recover after pulse application, this is reversible electroporation. If ...
Leto: 2018 Vir: Fakulteta za elektrotehniko (UL FE)
Identification and description of molecular transport mechanisms across cell membrane due to electroporation
Maria Scuderi, Lea Rems, Janja Dermol-Černe
Doktorska disertacija
Oznake: electroporation;electrochemotherapy;cisplatin;numerical modeling;molecu-lar transport;
Electroporation is a phenomenon which results in transient increase in cell membrane permeability for ions and molecules when exposing biological cells to short high-voltage electric pulses. If cells survive the exposure to electric pulses, electroporation is called reversible; otherwise, if cells d ...
Leto: 2024 Vir: Fakulteta za elektrotehniko (UL FE)
Short microsecond pulses achieve homogeneous electroporation of elongated biological cells irrespective of their orientation in electric field
Janja Dermol-Černe, Tina Batista Napotnik, Matej Reberšek, Damijan Miklavčič
Izvirni znanstveni članek
Oznake: elektroporacija;genska terapija;srčna ablacija;electroporation;gene therapy;cardiac ablation;
In gene electrotransfer and cardiac ablation with irreversible electroporation, treated muscle cells are typically of elongated shape and their orientation may vary. Orientation of cells in electric field has been reported to affect electroporation, and hence electrodes placement and pulse parameter ...
Leto: 2020 Vir: Fakulteta za elektrotehniko (UL FE)
High-intensity pulsed electromagnetic field-mediated gene electrotransfection in vitro
Matej Kranjc, Janja Dermol-Černe, Tjaša Potočnik, Vitalij Novickij, Damijan Miklavčič
Izvirni znanstveni članek
Oznake: elektromagnetno polje;elektroporacija;endocitoza;genska transfekcija;electromagnetic field;electroporation;endocytosis;gene transfection;
A high-intensity pulsed electromagnetic field (HI-PEMF) is a non-invasive and non-contact delivery method and may, as such, have an advantage over gene electrotransfer mediated by conventional electroporation using contact electrodes. Due to the limited number of in vitro studies in the field of gen ...
Leto: 2022 Vir: Fakulteta za elektrotehniko (UL FE)
Design, development, and testing of a device for gene electrotransfer to skin cells in vivo
Aleksandra Cvetkoska, Janja Dermol-Černe, Damijan Miklavčič, Simona Kranjc, Boštjan Markelc, Gregor Serša, Matej Reberšek
Izvirni znanstveni članek
Oznake: ekeltroporacija;elektroprenos genov;plazmidna DNK;electroporation;gene electrotransfer;plasmid DNA;
Gene electrotransfer (GET) is considered one of the most efficient, safe, reproducible, and cost-effective methods of gene therapy, in which a gene is delivered to the cells in the form of a plasmid DNA vector by a method known as electroporation. To achieve successful electroporation, cells must be ...
Leto: 2022 Vir: Fakulteta za elektrotehniko (UL FE)
Models of electroporation and the associated transmembrane molecular transport should be revisited
Maria Scuderi, Janja Dermol-Černe, Clarissa Amaral da Silva, Aswin Muralidharan, Pouyan E. Boukany, Lea Rems
Izvirni znanstveni članek
Oznake: elektropermeabilizacija;matematično modeliranje;elektrodifuzija;transport molekul;multifizika;modeliranje na več ravneh;electropermeabilization;mathematical modeling;electrodiffusion;molecular transport;multiphysics;multiscale;
Electroporation has become a powerful tool for nonviral delivery of various biomolecules such as nucleic acids, proteins, and chemotherapeutic drugs to virtually any living cell by exposing the cell membrane to an intense pulsed electric field. Different multiphysics and multiscale models have been ...
Leto: 2022 Vir: Fakulteta za elektrotehniko (UL FE)
Genska terapija v onkologiji, prvi razvojni koraki v Sloveniji
Maja Čemažar, Tanja Dolinšek, Maša Bošnjak, Boštjan Markelc, Urška Kamenšek, Simona Kranjc, Špela Kos, Urša Lampreht Tratar, Katarina Žnidar, Andrej Renčelj, Urška Matkovič, Teja Valant, Kristina Levpušček, Živa Modic, Tilen Komel, Tim Božič, Urša Kešar, Barbara Starešinič, Katja Uršič, Monika Štimac, Primož Strojan, Gorana Gašljević, Maja Ota, Aleš Grošelj, Črt Jamšek, Rosana Hudej, Matjaž Peterka, Franc Smrekar, Barbara Hubad, Marjan Hosta, Jaka Kužnik, Alojz Hosta, Damijan Miklavčič, Matej Reberšek, Aleksandra Cvetkoska, Anja Zajc, Janja Dermol-Černe, Nataša Tozon, Nina Milevoj, Alenka Nemec Svete, Gregor Serša
Strokovni članek
Oznake: genska terapija;interlevkin-12;plazmidna DNA;elektroprenos genov;rak kože;
Genska terapija postaja čedalje bolj zanimiva tudi v onkologiji. Med aplikacijami je morda najzanimivejša imunostimulacija. Pripravimo lahko plazmidno DNA, ki nosi zapis za različne imunostimulatorne molekule, ki jih vnesemo v celice tumorjev ali normalnih tkiv. Ta tkiva postanejo proizvajalci teh m ...
Leto: 2022 Vir: Onkološki inštitut Ljubljana (OI)
Št. zadetkov: 8
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