Št. zadetkov: 9
Magistrsko delo
Oznake:
TiO2;nanodelci;SH-SY5Y;nevrodegeneracija;ROS;diferenciacija;preživetje;
Namen magistrskega dela je bil določiti ali izbrani TiO2 nanodelci (ND) (ANATAZ, P25, FG) vplivajo na celice - preživetje, diferenciacijo, nastanek reaktivnih kisikovih zvrsti (ROS), proteine, ki so povezani z nevrodegenerativnimi spremembami, na modelu človeških nevralnih celic SH-SY5Y. Po vzpostav ...
Leto:
2020
Vir:
Biotehniška fakulteta (UL BF)
Pregledni znanstveni članek
Oznake:
non-canonical Wnt signalling pathway;bone mineral density;signalling crosstalk;osteogenesis;
The Wnt signalling pathway is one of the central signalling pathways in bone development, homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands, receptors and co-receptors, which ensure tight spatiotemporal regulation of Wnt signalling pathway activity and thus tigh ...
Leto:
2021
Vir:
Fakulteta za farmacijo (UL FFA)
Magistrsko delo
Oznake:
Osteoporoza;osteoblasti;diferenciacija;membranski palmitoirani protein 7 (MPP7);alkalna fosfataza (ALP);
Vsegenomske študije (GWAS; angl. Genome Wide Association Study) imajo pomembno vlogo pri iskanju novih terapevtskih tarč. S primerjavo pojavnosti genetskih variant pri zdravih in obolelih nam ta način preiskovanja omogoča lokalizacijo mest v genomu in prepoznavo genov (posredno tudi proteinov), ki v ...
Leto:
2021
Vir:
Fakulteta za farmacijo (UL FFA)
Diplomsko delo
Oznake:
tolu podobni receptor 5;mikrookolje;modulacija;HEK293;
The influence of chosen microenvironmental factors on toll-like rec eptor 5 signalling in human cell line HEK293
Leto:
2011
Vir:
Biotehniška fakulteta (UL BF)
Magistrsko delo
Oznake:
osteoporoza;osteoblasti;diferenciacija;mineralizacija;membranski palmitoirani protein 7 (MPP7);
Osteoporoza je kronična skeletna bolezen, za katero je značilna zmanjšana kostna masa in krhkost kosti. Zaradi pogostosti bolezni, poznega diagnosticiranja in hudih posledic nizkoenergetskih zlomov predstavlja osteoporoza še vedno velik javnozdravstveni problem. K pojavnosti osteoporoze prispevajo t ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
geNorm;reference gene;NormFinder;BestKeeper;osteogenic differentiation;gene expression;osteosarcoma cell line;RT-qPCR;
RT-qPCR is the gold standard and the most commonly used method for measuring gene expression. Selection of appropriate reference gene(s) for normalization is a crucial part of RT-qPCR experimental design, which allows accurate quantification and reliability of the results. Because there is no univer ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
nanodelci;nevrotoksičnost;izločanje citokinov;nanoparticle;neurotoxicity;cytokine secretion;
Environmental or biomedical exposure to nanoparticles (NPs) can results in translocation and accumulation of NPs in the brain, which can lead to health-related problems. NPs have been shown to induce toxicity to neuronal cells through several direct mechanisms, but only a few studies have also explo ...
Leto:
2020
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
nanotoksikologija;in vitro L6 mišična celična linija;urotelij;diferenciacija;celična signalizacija;ROS;nanotoxicology;in vitro L6 rat skeletal muscle cell line;urothelium in vitro;differentiation;cell signaling;
Many studies evaluated the short-term in vitro toxicity of nanoparticles (NPs); however, long-term effects are still not adequately understood. Here, we investigated the potential toxic effects of biomedical (polyacrylic acid and polyethylenimine coated magnetic NPs) and two industrial (SiO$_2$ and ...
Leto:
2020
Vir:
Fakulteta za elektrotehniko (UL FE)
Mojca Pavlin,
Jasna Lojk,
Klemen Strojan,
Iva Hafner Bratkovič,
Roman Jerala,
Adrijana Leonardi,
Igor Križaj,
Nataša Drnovšek,
Saša Novak,
Peter Veranič,
Vladimir Boštjan Bregar
Izvirni znanstveni članek
Oznake:
fizikalno-kemijske lastnosti;nanodelci;nanotoksikologija;imunski odziv;korelacija;proteinska korona;citokini;inflamasom;makrofagi;TiO2;physico-chemical properties;nanoparticles;nanotoxicology;immune response;correlation;protein corona;cytokines;inflammasome;macrophages;
Alongside physiochemical properties (PCP), it has been suggested that the protein corona of nanoparticles (NPs) plays a crucial role in the response of immune cells to NPs. However, due to the great variety of NPs, target cells, and exposure protocols, there is still no clear relationship between PC ...
Leto:
2022
Vir:
Fakulteta za elektrotehniko (UL FE)