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Št. zadetkov: 5
Potential revival of cholinesterase inhibitors as drugs in veterinary medicine
Neža Žnidaršič, Malan Štrbenc, Neža Grgurevič, Tomaž Snoj
Pregledni znanstveni članek
Oznake: cholinergic system;cholinesterase inhibitors;organophosphates;carbamates;canine cognitive dysfunction;cognitive dysfunction;dogs;
The cholinergic system is involved in the regulation of all organ systems and has acetylcholine (ACh) as almost its only neurotransmitter. Any substance is called cholinergic if it can alter the action of acetylcholine. Cholinesterases (ChEs) are enzymes that enable the hydrolysis of acetylcholine a ...
Leto: 2023 Vir: Veterinarska fakulteta (UL VF)
Nitrosative stress in the frontal cortex from dogs with canine cognitive dysfunction
Sonja Prpar, Maja Zakošek, Malan Štrbenc, Boris Rogelj, Gregor Majdič
Izvirni znanstveni članek
Oznake: Canine cognitive dysfunction;nitrosative stress;nNOS;eNOS;iNOS;3-nitrotyrosine;
Canine cognitive dysfunction (CCD) is an age-related disorder similar to human Alzheimer's disease (AD) that occurs in elderly dogs. Nitrosative stress has been implicated as one of the causes leading to neurodegenerative diseases, particularly AD. Its involvement in the development of CCD has not b ...
Leto: 2020 Vir: Veterinarska fakulteta (UL VF)
Rehoming and other refinements and replacement in procedures using golden hamsters in SARS-CoV-2 vaccine research
Malan Štrbenc, Urška Kuhar, Duško Lainšček, Sara Orehek, Brigita Slavec, Uroš Krapež, Tadej Malovrh, Gregor Majdič
Izvirni znanstveni članek
Oznake: vaccines;mesocricetus;Models;animal;SARS-CoV-2;
Effective vaccines are needed to fight the COVID-19 pandemic. Forty golden hamsters were inoculated with two promising vaccine candidates and eighteen animals were used in pilot trials with viral challenge. ELISA assays were performed to determine endpoint serum titres for specific antibodies and vi ...
Leto: 2023 Vir: Veterinarska fakulteta (UL VF)
Treatment of canine cognitive dysfunction with novel butyrylcholinesterase inhibitor
Maja Zakošek, Sonja Prpar, Malan Štrbenc, Urban Košak, Ilija Ilić, Jurij Trontelj, Simon Žakelj, Stanislav Gobec, Darja Pavlin, Gregor Majdič
Izvirni znanstveni članek
Oznake: Alzheimer’s disease;butyrylcholinesterase;butyrylcholinesterase inhibitor;canine cognitive dysfunction;canine dementia scale;dogs;
Canine cognitive dysfunction (CCD) is common in aged dogs and has many similarities with Alzheimer’s disease. Unfortunately, like Alzheimer’s disease, CCD cannot be cured. In the present study, we treated dogs with CCD with our newly developed and characterized butyrylcholinesterase inhibitor (BChEi ...
Leto: 2021 Vir: Veterinarska fakulteta (UL VF)
TXM peptides inhibit SARS-CoV-2 infection, syncytia formation, and lower inflamatory consequences
Tea Govednik, Duško Lainšček, Urška Kuhar, Marva Lachish, Sandra Janežič, Malan Štrbenc, Uroš Krapež, Roman Jerala, Daphne Atlas, Mateja Manček Keber
Izvirni znanstveni članek
Oznake: SARS-CoV-2;Disulfides;Thiol-reacting compound;Spike;Anti-inflammatory activity;
After three years of the SARS-CoV-2 pandemic, the search and availability of relatively low-cost benchtop therapeutics for people not at high risk for a severe disease are still ongoing. Although vaccines and new SARS-CoV-2 variants reduce the death toll, the long COVID-19 along with neurologic symp ...
Leto: 2024 Vir: Kemijski inštitut (KI)
Št. zadetkov: 5
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