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Št. zadetkov: 2
Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives
Maša Sinreih, Rebeka Jójárt, Zoltán Kele, Tomaž Büdefeld, Gábor Paragi, Erzsébet Mernyák, Tea Lanišnik-Rižner
Izvirni znanstveni članek
Oznake: aldo-keto reduktaze;halogenirani derivati estrona;zaviranje;
Facile syntheses of 3-O-carbamoyl, -sulfamoyl, or -pivaloyl derivatives of 13[alpha]-oestrone and its 17-deoxy counterpart have been carried out. Microwave-induced, Ni-catalysed Suzuki-Miyaura couplings of the newly synthesised phenol esters with phenylboronic acid afforded 3-deoxy-3-phenyl-13a-oest ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Cytotoxic effect of 13α-estrane derivatives on breast, endometrial and ovarian cancer cell lines
Alja Zottel, Rebeka Jójárt, Henrietta Ágoston, Eva Hafner, Neža Lipušček, Erzsébet Mernyák, Erzsébet Mernyák, Tea Lanišnik-Rižner, Tea Lanišnik-Rižner
Izvirni znanstveni članek
Oznake: breast cancer;endometrial cancer;ovarian cancer;estrane derivatives;cytotoxicity;
Hormone-dependent cancers such as breast, uterine, and ovarian cancers account for more than 35% of all cancers in women. Worldwide, these cancers occur in more than 2.7 million women/year and account for 22% of cancer-related deaths/year. The generally accepted mechanism for the pathophysiology of ...
Leto: 2023 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 2
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