Št. zadetkov: 10
Diplomsko delo
Oznake:
centri za socialno delo;reorganizacija;birokracija;informacijski sistem Krpan;kadri;institucionalna podpora;izobraževanje zaposlenih;terensko delo;supervizija;
V diplomski nalogi obravnavam problematiko reorganizacije centrov za socialno delo, ki se je uradno zgodila leta 2018 z združitvijo 62 centrov za socialno delo v novih 16 območnih centrov, s čimer se je obstoječih 62 centrov spremenilo v 63 enot. Žal se reorganizacija ni dotaknila vsebine dela na ce ...
Leto:
2020
Vir:
Fakulteta za socialno delo (UL FSD)
Magistrsko delo
Oznake:
spol;moški;moškost;socialno delo;socialni delavci;spolna neenakost;moški v netradicionalnih poklicih;
V nalogi obravnavamo vloge in položaje moških strokovnih delavcev, zaposlenih na centrih za socialno delo. Moški strokovni delavci so na področju socialnega dela zaposleni v veliki manjšini, večina teh v poklic vstopa nenačrtovano. Prav zaradi pomanjkanja so moški strokovni delavci bolj iskani in im ...
Leto:
2022
Vir:
Fakulteta za socialno delo (UL FSD)
Žiga Skok,
Michaela Barančokova,
Ondřej Benek,
Cristina Durante Cruz,
Päivi Tammela,
Tihomir Tomašić,
Nace Zidar,
Lucija Peterlin-Mašič,
Anamarija Zega,
Danijel Kikelj,
Janez Ilaš
Izvirni znanstveni članek
Oznake:
DNA gyrase;topoisomerase IV;GyrB;ParE;antibacterial benzothiazole;
We designed and synthesized a series of inhibitors of the bacterial enzymes DNA gyrase and DNA topoisomerase IV, based on our recently published benzothiazole-based inhibitor bearing an oxalyl moiety. To improve the antibacterial activity and retain potent enzymatic activity, we systematically explo ...
Leto:
2020
Vir:
Fakulteta za farmacijo (UL FFA)
Ákos Nyerges,
Tihomir Tomašić,
Martina Durcik,
Tamás Révész,
Petra Éva Szili,
Žiga Skok,
Nace Zidar,
Janez Ilaš,
Anamarija Zega,
Danijel Kikelj,
Lucija Peterlin-Mašič
Izvirni znanstveni članek
Oznake:
antibiotics;bacterial resistance;bacterial targets;
Antibiotics that inhibit multiple bacterial targets offer a promising therapeutic strategy against resistance evolution, but developing such antibiotics is challenging. Here we demonstrate that a rational design of balanced multitargeting antibiotics is feasible by using a medicinal chemistry workfl ...
Leto:
2020
Vir:
Fakulteta za farmacijo (UL FFA)
Žiga Skok,
Martina Durcik,
Živa Zajec,
Darja Gramec,
Krištof Bozovičar,
Anja Pišlar,
Tihomir Tomašić,
Anamarija Zega,
Lucija Peterlin-Mašič,
Danijel Kikelj,
Nace Zidar,
Janez Ilaš
Izvirni znanstveni članek
Oznake:
ATP-kompetitivni katalitični zaviralec;človeška DNA topoizomeraza II;anticancer;ATP-competitive;Catalytic inhibitor;cytotoxic;human DNA topoisomerase II;
ATP-competitive inhibitors of human DNA topoisomerase II show potential for becoming the successors of topoisomerase II poisons, the clinically successful anticancer drugs. Based on our recent screening hits, we designed, synthesized and biologically evaluated new, improved series of N-phenylpyrrola ...
Leto:
2023
Vir:
Fakulteta za farmacijo (UL FFA)
Martina Durcik,
Žiga Skok,
Janez Ilaš,
Nace Zidar,
Anamarija Zega,
Petra Éva Szili,
Gábor Draskovits,
Tamás Révész,
Danijel Kikelj,
Ákos Nyerges,
Csaba Pál,
Lucija Peterlin-Mašič,
Tihomir Tomašić
Izvirni znanstveni članek
Oznake:
antibacterial;ciprofloxacin;DNA gyrase;dual inhibitor;hybrid;
The discovery of multi-targeting ligands of bacterial enzymes is an important strategy to combat rapidly spreading antimicrobial resistance. Bacterial DNA gyrase and topoisomerase IV are validated targets for the development of antibiotics. They can be inhibited at their catalytic sites or at their ...
Leto:
2021
Vir:
Fakulteta za farmacijo (UL FFA)
Andrej Emanuel Cotman,
Martina Durcik,
Davide Benedetto Tiz,
Federica Fulgheri,
Maša Sterle,
Štefan Možina,
Žiga Skok,
Nace Zidar,
Anamarija Zega,
Janez Ilaš,
Lucija Peterlin-Mašič,
Tihomir Tomašić,
Danijel Kikelj
Izvirni znanstveni članek
Oznake:
antibacterial activity;bacteria;genetics;inhibitors;solubility;
We have developed compounds with a promising activity against Acinetobacter baumannii and Pseudomonas aeruginosa, which are both on the WHO priority list of antibiotic-resistant bacteria. Starting from DNA gyrase inhibitor 1, we identified compound 27, featuring a 10-fold improved aqueous solubility ...
Leto:
2023
Vir:
Fakulteta za farmacijo (UL FFA)
Martina Durcik,
Andrej Emanuel Cotman,
Žan Toplak,
Štefan Možina,
Žiga Skok,
Maria Vittoria Piras,
Nace Zidar,
Janez Ilaš,
Anamarija Zega,
Jurij Trontelj,
Danijel Kikelj,
Tihomir Tomašić,
Lucija Peterlin-Mašič
Izvirni znanstveni članek
Oznake:
antibacterial activity;bacteria;inhibitors;
A new series of dual low nanomolar benzothiazole inhibitors of bacterial DNA gyrase and topoisomerase IV were developed. The resulting compounds show excellent broad-spectrum antibacterial activities against Gram-positive Enterococcus faecalis, Enterococcus faecium and multidrug resistant (MDR) Stap ...
Leto:
2023
Vir:
Fakulteta za farmacijo (UL FFA)
Nace Zidar,
Alessia Onali,
Peter Peršolja,
Davide Benedetto Tiz,
Jaka Dernovšek,
Žiga Skok,
Martina Durcik,
Andrej Emanuel Cotman,
Martina Hrast,
Anamarija Zega,
Lucija Peterlin-Mašič,
Janez Ilaš,
Tihomir Tomašić,
Danijel Kikelj
Izvirni znanstveni članek
Oznake:
antibacterial;DNA gyrase;GyrB;inhibitor;N-phenylpyrrolamide;ParE;topoisomerase IV;
In this work, we describe an improved series of N-phenylpyrrolamide inhibitors that exhibit potent activity against DNA gyrase and are highly effective against high-priority gram-positive bacteria. The most potent compounds show low nanomolar IC50 values against Escherichia coli DNA gyrase, and in a ...
Leto:
2024
Vir:
Fakulteta za farmacijo (UL FFA)
Andrej Emanuel Cotman,
Federica Fulgheri,
Martina Piga,
Peter Peršolja,
Davide Benedetto Tiz,
Žiga Skok,
Martina Durcik,
Maša Sterle,
Jaka Dernovšek,
Anamarija Zega,
Lucija Peterlin-Mašič,
Janez Ilaš,
Tihomir Tomašić,
Danijel Kikelj,
Nace Zidar
Izvirni znanstveni članek
Oznake:
N-fenilpirolamidni inhibitorji;bakterijske DNA giraze;sinteza spojin;antibakterijsko delovanje;
This study presents the discovery of a new series of N-phenylpyrrolamide inhibitors of bacterial DNA gyrase with improved antibacterial activity. The most potent inhibitors had low nanomolar IC50 values against Escherichia coli DNA gyrase (IC50; 2–20 nM) and E. coli topoisomerase IV (22i, IC50 = 143 ...
Leto:
2024
Vir:
Fakulteta za farmacijo (UL FFA)