Št. zadetkov: 11
Izvirni znanstveni članek
Oznake:
cathepsin x regulation;enolase isoforms;neuronal specific subtype;neurotrophic activity;γ-enolase;
Neuronal differentiation into specific subtypes is crucial for nervous system development and function, guided by neurotrophic factors. γ-Enolase, a neuron-specific glycolytic enzyme, exhibits neurotrophic-like properties and supports neuronal differentiation; however, its role in specific neuronal ...
Leto:
2026
Vir:
Fakulteta za farmacijo (UL FFA)
Magistrsko delo
Oznake:
mikroglija;polarizacija;vnetje;katepsin X;zaviralec katepsina X;
Celice mikroglije so glialne celice centralnega živčnega sistema (CŽS), podobne makrofagom, ki vzdržujejo homeostazo možganov in so ene izmed najpomembnejših prirojenih celic imunskega sistema v CŽS. Pod vplivom patoloških in imunoloških dražljajev pride do polarizacije mikroglije v pro-vnetni fenot ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
fizika;membrane;fluorescenca;
Plasma membranes are vital biological structures, serving as protective barriers and participating in various cellular processes. In the field of super-resolution optical microscopy, stimulated emission depletion (STED) nanoscopy has emerged as a powerful method for investigating plasma membrane-rel ...
Leto:
2024
Vir:
Institut Jožef Stefan (IJS)
Izvirni znanstveni članek
Oznake:
butyrylcholinesterase;acetylcholinesterase;monoamine oxidase;monoamine oxidase A;monoamine oxidase B;enzyme inhibitors;pyrrolidines;
Butyrylcholinesterase (BChE) inhibitors are or could be used for the treatment of Alzheimer's disease, canine cognitive dysfunction, depression, multiple sclerosis, heroin abuse and metabolic disorders. Monoamine oxidase (MAO) inhibitors are or could be used for the treatment of depression, anxiety, ...
Leto:
2025
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
butyrylcholinesterase;p38α mitogen-activated protein kinase;dual inhibitors;carbamate;pseudo-irreversible inhibition;
Given the limited benefits of anticholinergic drugs and the repeated clinical failures of anti-amyloid therapies, the therapeutic focus in Alzheimer's disease (AD) is gradually shifting toward addressing both disease symptoms and its major underlying cause – neuroinflammation. We have developed nove ...
Leto:
2025
Vir:
Fakulteta za farmacijo (UL FFA)
Svit Ferjančič Benetik,
Matic Proj,
Damijan Knez,
Urban Košak,
Anže Meden,
Katja Krajšek,
Anja Hafner,
Selena Horvat,
Urban Švajger,
Nataša Tešić,
Aleš Obreza,
Stanislav Gobec
Izvirni znanstveni članek
Oznake:
central nervous system;inhibition;inhibitors;peptides and proteins;rodent models;
The currently approved drugs for the treatment of Alzheimer’s disease (AD) fail to address its interconnected pathological processes. Inhibition of butyrylcholinesterase (BChE) and p38α mitogen-activated protein kinase (p38α MAPK) offers an innovative dual approach to mitigate two major drivers of n ...
Leto:
2025
Vir:
Fakulteta za farmacijo (UL FFA)
Urban Košak,
Nika Strašek,
Damijan Knez,
Simon Žakelj,
Jurij Trontelj,
Anja Hafner,
Selena Horvat,
Aljoša Bolje,
Neža Žnidaršič,
Neža Grgurevič,
Tanja Švara,
Jakob Kljun,
Jure Stojan,
Stanislav Gobec
Izvirni znanstveni članek
Oznake:
centralni živčni sistem;odkrivanje zdravil;inhibitorji;presejalni testi;sulfoni;central nervous system;drug discovery;inhibitors;screening assays;sulfones;
Butyrylcholinesterase (BChE) is a promising drug target for alleviating the symptoms of canine cognitive dysfunction (CCD) and Alzheimer’s disease (AD). We have recently developed lead compound 2, a racemic, nanomolar BChE inhibitor with procognitive effects in mice with scopolamine-induced AD-like ...
Leto:
2025
Vir:
Fakulteta za farmacijo (UL FFA)
Anže Meden,
Neža Žnidaršič,
Damijan Knez,
Yuanyuan Wang,
Ziwei Xu,
Huajing Yang,
Weiting Zhang,
Anja Hafner,
Andrej Perdih,
Simona Kranjc,
Neža Grgurevič,
Stane Pajk,
Haopeng Sun,
Stanislav Gobec
Izvirni znanstveni članek
Oznake:
pleiotropic prodrug;Alzheimer’s disease;butyrylcholinesterase;α2A adrenoreceptor;disease-modifying treatment;N-heterocyclic ureas;carbamates;neurodegenerative diseases;
The inherent complexity of Alzheimer’s disease (AD) and failed clinical trials have spiked the interest in multifunctional ligands that target at least two key disease-associated macromolecules in AD pathology. Here we present a focused series of pleiotropic N-carbamoylazole prodrugs with dual mecha ...
Leto:
2025
Vir:
Veterinarska fakulteta (UL VF)
Diplomsko delo
Oznake:
Zaposlitev;Trg dela;Brezposelnost;Strah;Socialna država;
Strah pred izgubo zaposlitve
Leto:
2009
Vir:
Fakulteta za družbene vede (UL FDV)
Diplomsko delo
Oznake:
Vzgoja za zdravo spolnost z vidika mladostnikov
Leto:
2014
Vir:
Visoka šola za zdravstveno nego Jesenice (VŠZNJ)