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Št. zadetkov: 5
ǂThe ǂconserved arginine cluster in the insert of the third cytoplasmic loop of the long form of the D2 dopamine receptor (D2L-R) acts as an intracellular retention signal
Valentina Kubale, Kaja Blagotinšek Cokan, Jane N. Larsen, Karin A Eidne, Milka Vrecl
Izvirni znanstveni članek
Oznake: D$_2$ dopamine receptors;endoplasmic reticulum (ER) retention motif;confocal microscopy;surface expression;bioluminescence resonance energy transfer (BRET$^2$);cAMP signaling;molecular biology;energy transfer techniques;metabolism;
This study examined whether the conserved arginine cluster present within the 29-amino acid insert of the long form of the D$_2$ dopamine receptor (D$_{2L}$-R) confers its predominant intracellular localization. We hypothesized that the conserved arginine cluster (RRR) located within the insert coul ...
Leto: 2016 Vir: Veterinarska fakulteta (UL VF)
Razvoj hepatocelularnega karcinoma pri miših kot posledica prekinjene sinteze holesterola zaradi izbitja gena CYP51 v jetrih
Kaja Blagotinšek Cokan, Damjana Rozman, Katarina Trebušak Podkrajšek, Tea Lanišnik-Rižner, Gregor Majdič
Doktorska disertacija
Oznake: hepatocelularni karcinom;sinteza holesterola;gen CYP51;Bolezni prebavil;Disertacije;Bolezni jeter;Hepatocelularni karcinom;Presnova;Onkologija;Diseracije;Rak;Hepatocite;Mutacije;Geni;Kancerogeneza;Molekularna biologija;Translacija;
Hepatocelularni karcinom (HCC) v svetovnem merilu predstavlja drugi najpogostejši z rakom povezani vzrok smrti. Kljub obsežni etiologiji HCC je vse več dokazov, da so moteni presnovni procesi v jetrih prevladujoči vzrok za nastanek HCC, ki prispeva k nastanku z več dejavniki in s presnovo povezanih ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Critical impact of different conserved endoplasmic retention mofits and dopamine receptor interacting proteins (DRIPs) on intracellular localization and trafficking of the D2 dopamine receptor (D2-R) isoforms
Kaja Blagotinšek Cokan, Maša Mavri, Catrin Rutland, Sanja Glisic, Milan Sencanski, Milka Vrecl, Valentina Kubale
Pregledni znanstveni članek
Oznake: D$_2$ dopamine receptor;intracellular trafficking;endoplasmic reticulum;retention motifs;ICL3;interacting partners;
The type 2 dopamine receptor D2 (D2-R), member of the G protein-coupled receptor (GPCR) superfamily, exists in two isoforms, short (D2S-R) and long (D2L-R). They differ by an additional 29 amino acids (AA) in the third cytoplasmic loop (ICL3) of the D2L-R. These isoforms differ in their intracellula ...
Leto: 2020 Vir: Medicinska fakulteta (UL MF)
Common transcriptional program of liver fibrosis in mouse genetic models and humans
Kaja Blagotinšek Cokan, Žiga Urlep, Miha Moškon, Miha Mraz, Xiang Yi Kong, Winnie Eskild, Damjana Rozman, Peter Juvan, Tadeja Režen
Izvirni znanstveni članek
Oznake: žolčna kislina;maščobna kislina;fibroza;bile acid;fatty acid;fibrosis;
Multifactorial metabolic diseases, such as non-alcoholic fatty liver disease, are a major burden to modern societies, and frequently present with no clearly defined molecular biomarkers. Herein we used system medicine approaches to decipher signatures of liver fibrosis in mouse models with malfuncti ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Chronic disruption of the late cholesterol synthesis leads to female-prevalent liver cancer
Kaja Blagotinšek Cokan, Žiga Urlep, Gregor Lorbek, Madlen Matz-Soja, Cene Skubic, Martina Perše, Jera Jeruc, Peter Juvan, Tadeja Režen, Damjana Rozman
Izvirni znanstveni članek
Oznake: biosinteza holesterola;hepatocelularni karcinom;spolni dimorfizem;cholesterol biosynthesis;hepatocellular carcinoma;sex dimorphism;
While the role of cholesterol in liver carcinogenesis remains controversial, hepatocellular carcinoma generally prevails in males. Herein, we uncover pathways of female-prevalent progression to hepatocellular carcinoma due to chronic repression of cholesterogenic lanosterol 14[alpha]-demethylase (CY ...
Leto: 2020 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 5
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