Št. zadetkov: 14
Doktorska disertacija
Oznake:
molekularna biologija;celična membran;človeški herpesvirus 4;prašičji herpesvirus;receptor;sklopljen z G-proteinom;protein transport – fiziologija;prenos signalov;endocitoza;kaveolin;klatrin;dynamin;
Cilj disertacije sta opredelitev in primerjava molekularnih in bioloških lastnosti ortologov BILF1, kodiranih v treh prašičjih limfotropnih herpesvirusih (PLHV1-3) in humanem virusu Epstein-Barr (EBV). Proučevali smo lokalizacijo, konstitutivno internalizacijo, konstitutivno aktivnost in imunoregula ...
Leto:
2023
Vir:
Veterinarska fakulteta (UL VF)
Pregledni znanstveni članek
Oznake:
endocytosis;G-protein coupled receptors;herpesvirus;methods;Herpesviridae;
Endocytosis is a fundamental process involved in trafficking of various extracellular and transmembrane molecules from the cell surface to its interior. This enables cells to communicate and respond to external environments, maintain cellular homeostasis, and transduce signals. G protein-coupled rec ...
Leto:
2020
Vir:
Veterinarska fakulteta (UL VF)
Pregledni znanstveni članek
Oznake:
D$_2$ dopamine receptor;intracellular trafficking;endoplasmic reticulum;retention motifs;ICL3;interacting partners;
The type 2 dopamine receptor D2 (D2-R), member of the G protein-coupled receptor (GPCR) superfamily, exists in two isoforms, short (D2S-R) and long (D2L-R). They differ by an additional 29 amino acids (AA) in the third cytoplasmic loop (ICL3) of the D2L-R. These isoforms differ in their intracellula ...
Leto:
2020
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
Herpesvirus 4;human;Dynamins;Caveolins;beta-Arrestins;
Background: The viral G protein-coupled receptor (vGPCR) BILF1 encoded by the Epstein-Barr virus (EBV) is an oncogene and immunoevasin and can downregulate MHC-I molecules at the surface of infected cells. MHC-I downregulation, which presumably occurs through co-internalization with EBV-BILF1, is pr ...
Leto:
2023
Vir:
Veterinarska fakulteta (UL VF)
Izvirni znanstveni članek
Oznake:
pigs;dietary supplements;tannins;parotid gland;mandibular gland;immunohistochemistry;histology;proline-rich proteins (PRP);swine;
The ingestion of hydrolysable tannins as a potential nutrient to reduce boar odor in entire males results in the significant enlargement of parotid glands (parotidomegaly). The objective of this study was to characterize the effects of different levels of hydrolysable tannins in the diet of fattenin ...
Leto:
2022
Vir:
Veterinarska fakulteta (UL VF)
Naotaka Tsutsumi,
Qianhui Qu,
Maša Mavri,
Maibritt S. Baggesen,
Shoji Maeda,
Deepa Waghray,
Christian Berg,
Brian K. Kobilka,
Mette Marie Rosenklide,
Georgios Skiniotis,
K. Christopher Garcia
Izvirni znanstveni članek
Oznake:
Epstein-Barr virus;G protein;G protein-coupled receptor;GPCR;cryo-EM;immune evasion;ligand-indpendent signaling;receptor;signaling;viral GPCR;
Epstein-Barr virus (EBV) encodes a G protein-coupled receptor (GPCR) termed BILF1 that is essential for EBV-mediated immunosuppression and oncogenesis. BILF1 couples with inhibitory G protein (Gi), the major intracellular signaling effector for human chemokine receptors, and exhibits constitutive si ...
Leto:
2021
Vir:
Veterinarska fakulteta (UL VF)
Izvirni znanstveni članek
Oznake:
GTP-binding proteins;monocyte chemoattractant proteins;macrophage inflammatory proteins;receptors;chemokine;
Extensive ligand-receptor promiscuity in the chemokine signaling system balances beneficial redundancy and specificity. However, this feature poses a major challenge to selectively modulate the system pharmacologically. Here, we identified a conserved cluster of three aromatic receptor residues that ...
Leto:
2022
Vir:
Veterinarska fakulteta (UL VF)
Astrid S. Jørgensen,
Viktorija Daugvilaite,
Katia De Filippo,
Christian Berg,
Maša Mavri,
Tau Benned-Jensen,
Goda Juzenaite,
Gertrud Malene Hjortø,
Sara Rankin,
Jon Våbenø,
Mette Marie Rosenklide
Izvirni znanstveni članek
Oznake:
stem cells;hematopoietic stem cells;GTP-binding proteins;molecular medicine;receptor pharmacology;
Following the FDA-approval of the hematopoietic stem cell (HSC) mobilizer plerixafor, orally available and potent CXCR4 antagonists were pursued. One such proposition was AMD11070, which was orally active and had superior antagonism in vitro; however, it did not appear as effective for HSC mobilizat ...
Leto:
2021
Vir:
Veterinarska fakulteta (UL VF)
Maša Mavri,
Valentina Kubale,
Daniel P. Depledge,
Jianmin Zuo,
Christene A. Huang,
Judith Breuer,
Milka Vrecl,
Michael A. Jarvis,
Eva Jarc,
Toni Petan,
Bernhard Ehlers,
Mette Marie Rosenklide,
Katja Spiess
Izvirni znanstveni članek
Oznake:
Epstein-Barr virus;porcine lymphotropic herpesviruses (PLHV);BILF1;G protein signaling;MHC class I;drug target;post-transplant lymphoproliferative disease;in-vivo model;
Infection of immunosuppressed transplant patients with the human γ-herpesvirus Epstein-Barr virus (EBV) is associated with post-transplant lymphoproliferative disease (PTLD), an often fatal complication. Immunosuppressed miniature pigs infected with γ-herpesvirus porcine lymphotropic herpesvirus 1 ( ...
Leto:
2022
Vir:
Veterinarska fakulteta (UL VF)
Magistrsko delo
Oznake:
ekstrakcija;izolacija;polifenoli;antioksidativni učinek;viabilnost celic;MTT test;magistrske naloge;
V magistrskem delu smo pripravili ekstrakte aronije iz liofoliziranih plodov aronije. Ekstrakti so bili pripravljeni s superkritično in s konvencionalno ekstrakcijo. Superkritično ekstrakcijo s topilom CO2 in kotopilom etanolom smo izvedli pri pogojih: 100, 200 in 300 barih ter temperaturah 40 oz. 6 ...
Leto:
2018
Vir:
Fakulteta za kemijo in kemijsko tehnologijo (UM FKKT)