Št. zadetkov: 10
Izvirni znanstveni članek
Oznake:
Intramolecular sensitization;structure of a conjugate;paraoxonase 1;
Paraoxonase 1 (PON1) is a Ca2+-dependent enzyme involved in oxidative stress processes and is widely studied for its protective roles in various diseases. Intermolecular sensitization of lanthanide ions was implemented by replacing Ca2+ ions from the recombinant PON1 (rePON1) catalytic site in the p ...
Leto:
2025
Vir:
Medicinska fakulteta (UL MF)
Magistrsko delo
Oznake:
paraoksonaza 1;encimska inhibicija;kompetitivni inhibitorji;encimska kinetika;
Cilj magistrskega dela je bil identificirati nove kompetitivne inhibitorje rekombinantnega encima paraoksonaza 1 (rePON1), ki bi lahko z višjo afiniteto nadomestili že znani inhibitor 2-hidroksikinolin (2HQ). PON1 je od kalcija odvisna sesalska hidrolaza, ki sodeluje v zaščiti pred oksidativnim stre ...
Leto:
2025
Vir:
Medicinska fakulteta (UL MF)
Doktorska disertacija
Oznake:
paraoksonaza 1;lantanoidi;terbij;fosforescenca;ternarni kompleks;
Paraoksonaza 1 (PON1) je ključen od Ca2+ ionov odvisen hidrolitičen encim, vezan na lipoproteine visoke gostote (HDL), katerega aktivnost in koncentracija sta tesno povezani s številnimi bolezenskimi stanji oksidativnega stresa, vključno s srčno-žilnimi in nevrodegenerativnimi obolenji. Kljub intenz ...
Leto:
2025
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
paraoxonase;lactonase;oxidative stress;
Serum paraoxonase-1 (PON1) is the most studied member of the group of paraoxonases (PONs). This enzyme possesses three enzymatic activities: lactonase, arylesterase, and paraoxonase activity. PON1 and its isoforms play an important role in drug metabolism as well as in the prevention of cardiovascul ...
Leto:
2020
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
paraoksonaza 1;dihidrokumarin;krivulje napredka;paraoxonase 1;dihydrocoumarin;progress curves;
Several approaches for determining an enzyme’s kinetic parameter Km (Michaelis constant) from progress curves have been developed in recent decades. In the present article, we compare different approaches on a set of experimental measurements of lactonase activity of paraoxonase 1 (PON1): (1) a diff ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
paraoxonase-1;arylesterase activity;reversible inhibition;
Mammalian paraoxonase-1 hydrolyses a very broad spectrum of esters such as certain drugs and xenobiotics. The aim of this study was to determine whether carbamates influence the activity of recombinant PON1 (rePON1). Carbamates were selected having a variety of applications: bambuterol and physostig ...
Leto:
2020
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
cattle - metabolism;liver - physiology;adipose tissue;postpartum period;bovine liver;fat;glycogen;indication;
The objective was to determine optimal thresholds of blood variables that are associated withliver lipid and glycogen content in dairy cows. Liver specimens of 15 Holstein dairy cows weretaken 2 weeks postpartum (PP) and used for determination of lipid and glycogen content,respectively. Blood sample ...
Leto:
2020
Vir:
Veterinarska fakulteta (UL VF)
Izvirni znanstveni članek
Oznake:
Parkinsonova bolezen;kognitivne motnje;paraoksonaza 1;Parkinson disease;cognitive impairment;paraoxonase 1;
Cognitive impairment is a common non-motor symptom of Parkinson’s disease (PD), which often progresses to PD dementia. PD patients with and without dementia may differ in certain biochemical parameters, which could thus be used as biomarkers for PD dementia. The enzyme paraoxonase 1 (PON1) has previ ...
Leto:
2023
Vir:
Medicinska fakulteta (UL MF)
Druge monografije in druga zaključena dela
Oznake:
maligni limfomi;zdravljenje;bolniki;
Obravnava bolnikov z malignimi limfomi, Ljubljana, 25. oktober 2019
Leto:
2019
Vir:
Onkološki inštitut Ljubljana (OI)
Rok Kamnik,
Marko Jaušovec,
Matjaž P. Nekrep,
Saša Djura Jelenko,
Darja Čepin,
Nejc Gonza,
Aleksandra Korpič,
Aneja Lah,
Zala Popič,
Klara Šoster,
Katja Goličnik,
Simon Harc,
Stanislav Hozjan,
Kristina Tomiek,
Vid Markota,
Matjaž Pongrac
Končno poročilo o rezultatih raziskav
Oznake:
arheologija;domoznanstvo;turške šance;
Arheološki park Turške šance "Šance za zanamce"
Leto:
2020
Vir:
Fakulteta za gradbeništvo, prometno inženirstvo in arhitekturo (UM FGPA)