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Št. zadetkov: 3
Integration of genomic and transcriptomic data of inbred mouse models for polygenic obesity and leanness revealed “obese” and “lean” candidate alleles in polyadenylation signals
Martin Šimon, Špela Mikec, Nicholas M. Morton, Santosh S. Atanur, Simon Horvat, Tanja Kunej
Izvirni znanstveni članek
Oznake: genetika;genomika;transkriptomika;debelost;mišji modeli;kandidatni alali;
Most mammalian genes have multiple polyadenylation (PA) sites, and alternative polyadenylation (APA) has been linked to diseases such as obesity. Studies have shown that changes in the polyadenylation signal (PAS) can influence the efficiency of cleavage and affect disease susceptibility and phenoty ...
Leto: 2024 Vir: Biotehniška fakulteta (UL BF)
Genome-wide screening for genetic variants in polyadenylation signal (PAS) sites in mouse selection lines for fatness and leanness
Martin Šimon, Špela Mikec, Nicholas M. Morton, Santosh S. Atanur, Janez Konc, Simon Horvat, Tanja Kunej
Izvirni znanstveni članek
Oznake: debelost;mišji modeli;debela linija;vitka linija;genetika;alternativna poliadenilacija;
Alternative polyadenylation (APA) determines mRNA stability, localisation, translation and protein function. Several diseases, including obesity, have been linked to APA. Studies have shown that single nucleotide polymorphisms in polyadenylation signals (PAS-SNPs) can influence APA and affect phenot ...
Leto: 2023 Vir: Biotehniška fakulteta (UL BF)
Whole genome sequencing of mouse lines divergently selected for fatness (FLI) and leanness (FHI) revealed several genetic variants as candidates for novel obesity genes
Martin Šimon, Špela Mikec, Santosh S. Atanur, Janez Konc, Nicholas M. Morton, Simon Horvat, Tanja Kunej
Izvirni znanstveni članek
Oznake: debelost;mišji modeli;genetika;genomika;kandidatni geni;
Background Analysing genomes of animal model organisms is widely used for understanding the genetic basis of complex traits and diseases, such as obesity, for which only a few mouse models exist, however, without their lean counterparts. Objective To analyse genetic differences in the unique mouse ...
Leto: 2024 Vir: Biotehniška fakulteta (UL BF)
Št. zadetkov: 3
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