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Št. zadetkov: 8
Samostojni znanstveni sestavek ali poglavje v monografski publikaciji
Oznake: analitske metode;biološki vzorci;interakcije zdravil;metabolizem zdravil;
Analytical methods for quantification of drug metabolites in biological samples
Leto: 2012 Vir: Fakulteta za farmacijo (UL FFA)
Pregledni znanstveni članek
Oznake: metabolizem;zdravilne učinkovine;eksperimentalni modeli;in vitro modeli;subcelične frakcije;
V prispevku so sistematično predstavljeni eksperimentalni modeli za preučevanje jetrnega metabolizma učinkovin in vitro. Opisani so naslednji modeli po rastoči stopnji kompleksnosti: rekombinantni encimi, mikrosomi, citosol, S9 frakcija, izolirani hepatociti, celične linije, jetrne rezine in perfund ...
Leto: 2011 Vir: Fakulteta za farmacijo (UL FFA)
Diplomsko delo
Oznake: revmatoidni artritis;farmakokinetično modeliranje;leflunomid;populacijska farmakokinetika;bolniki;
Leto: 2008 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: raloksifen;UGT1A1*28;polimorfizem;farmakokinetika;
Raloxifene, a selective estrogen receptor modulator, exhibits quite large inter individual variability in pharmacokinetics and pharmacodynamics. In women, raloxifene is extensively metabolized by different isoforms of UDP-glucuronosyltransferase (UGT) to its glucuronides. In order to gain an insight ...
Leto: 2011 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: bisfenol A;mikrosomi;masna spektrometrija;tekočinska kromatografija;UDP glukuronoziltransferaza;
The endocrine disruptor bisphenol A (BPA) is a frequently used chemical in the manufacture of consumer products. In humans, BPA is extensively metabolised to BPA glucuronide (BPAG) by different UDP-glucuronosyltransferase (UGT) isoforms. The study has been performed with the intention to improve the ...
Leto: 2012 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: bazedoksifen;raloksifen;LC-MS/MS;citokrom P450;osteporoza;
Bazedoxifene is a selective estrogen receptor modulator (SERM) that has been developed for use in post-menopausal osteoporosis. However, it contains a potentially toxic 5-hydroxy-3-methylindole moiety. Previous studies on the 5-hydroxyindole and the 3-alkylindole-containing drugs indometacine, zafir ...
Leto: 2012 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: raloksifen;osteoporoza;SLCO1B1;SLCO1B3;
Raloxifene, a selective estrogen receptor modulator, exhibits quite large and unexplained interindividual variability in pharmacokinetics and pharmacodynamics. The aim of this study was to determine the role of organic-anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants in ...
Leto: 2012 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: raloksifen;osteoporoza;zdravljenje;farmakokinetika;farmakodinamika;
Raloxifene exhibits a large and unexplained interindividual variability in its pharmacokinetics and pharmacodynamics. The aim of our study was to identify transporters involved in the efflux of raloxifene and its glucuronide metabolites by various in vitro models and by an in vivo study to explore t ...
Leto: 2012 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 8
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