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Št. zadetkov: 9
Samostojni znanstveni sestavek ali poglavje v monografski publikaciji
Oznake: analitske metode;biološki vzorci;interakcije zdravil;metabolizem zdravil;
Leto: 2012 Vir: Fakulteta za farmacijo (UL FFA)
Pregledni znanstveni članek
Oznake: metabolizem;zdravilne učinkovine;eksperimentalni modeli;in vitro modeli;subcelične frakcije;
V prispevku so sistematično predstavljeni eksperimentalni modeli za preučevanje jetrnega metabolizma učinkovin in vitro. Opisani so naslednji modeli po rastoči stopnji kompleksnosti: rekombinantni encimi, mikrosomi, citosol, S9 frakcija, izolirani hepatociti, celične linije, jetrne rezine in perfund ...
Leto: 2011 Vir: Fakulteta za farmacijo (UL FFA)
Diplomsko delo
Oznake: revmatoidni artritis;farmakokinetično modeliranje;leflunomid;populacijska farmakokinetika;bolniki;
Leto: 2008 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: raloksifen;UGT1A1*28;polimorfizem;farmakokinetika;
Raloxifene, a selective estrogen receptor modulator, exhibits quite large inter individual variability in pharmacokinetics and pharmacodynamics. In women, raloxifene is extensively metabolized by different isoforms of UDP-glucuronosyltransferase (UGT) to its glucuronides. In order to gain an insight ...
Leto: 2011 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: bisfenol A;mikrosomi;masna spektrometrija;tekočinska kromatografija;UDP glukuronoziltransferaza;
The endocrine disruptor bisphenol A (BPA) is a frequently used chemical in the manufacture of consumer products. In humans, BPA is extensively metabolised to BPA glucuronide (BPAG) by different UDP-glucuronosyltransferase (UGT) isoforms. The study has been performed with the intention to improve the ...
Leto: 2012 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: sakvinavir;česnov ekstrakt;darunavir;proteazni inhibitorji;AIDS;CYP3A4;
Background/Aims. The aim of this study was to elucidate the impact of first-pass intestinal metabolism to therapeutic efficacy of antiretrovirals and to ascertain interaction mechanisms between garlic supplements (aged garlic extract) and HIV-protease inhibitors. Methods. In vitro permeability throu ...
Leto: 2010 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: raloksifen;urin;farmakokinetika;doping;
A selective, sensitive, accurate and precise liquid chromatography-tandem massspectrometry (LC-MS/MS) method for determination of raloxifene and its three glucuronides: raloxifene6 bglucuronide (M1), raloxifene4 0 bglucuronide (M2), raloxifene6,4 0diglucuronide (M3) in urine samples is presented in ...
Leto: 2011 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: bazedoksifen;raloksifen;LC-MS/MS;citokrom P450;osteporoza;
Bazedoxifene is a selective estrogen receptor modulator (SERM) that has been developed for use in post-menopausal osteoporosis. However, it contains a potentially toxic 5-hydroxy-3-methylindole moiety. Previous studies on the 5-hydroxyindole and the 3-alkylindole-containing drugs indometacine, zafir ...
Leto: 2012 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: raloksifen;osteoporoza;SLCO1B1;SLCO1B3;
Raloxifene, a selective estrogen receptor modulator, exhibits quite large and unexplained interindividual variability in pharmacokinetics and pharmacodynamics. The aim of this study was to determine the role of organic-anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants in ...
Leto: 2012 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 9
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