Št. zadetkov: 12
Diplomsko delo
Oznake:
diplomska dela;montessori pedagogika;waldorfska pedagogika;slovenščina;pouk;učenci;razvoj;učitelji;
Izobraževanje ima pomembno vlogo v družbi. Klasična šola, kot jo poznamo danes, se je razvijala skozi vso zgodovino človeštva. Prav tako so se ob njej razvijale tudi različne druge oblike izobraževanja oziroma pedagogik. Zanimalo nas je, kateri pogledi teh pedagogik bi lahko pozitivno vplivali na kl ...
Leto:
2016
Vir:
Filozofska fakulteta (UM FF)
Magistrsko delo
Oznake:
Tollu-podobni receptorji;TLR7;agonist;6-(trifluorometil)izoksazolo[5;4-
d]pirimidin;
Tollu podobni receptorji (TLR) so pomembna skupina receptorjev, ki igrajo ključno vlogo v
prirojenem in pridobljenem imunskem sistemu. So obetavne tarče za zdravljenje okužb,
avtoimunskih bolezni in raka. Pri človeku so do sedaj odkrili 10 različnih tipov TLR. V okviru
magistrske naloge smo se osred ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)
Magistrsko delo
Oznake:
ozaveščenost učiteljev;posebne potrebe;prototip;aplikacija;tehnologija za izobraževalne namene;komunikacija;
Magistrska naloga se osredotoča na razvoj prototipa aplikacije, namenjene podpori otrokom s posebnimi potrebami v izobraževalnem procesu. Izvedli smo kvalitativno analizo potreb in izzivov, s katerimi se srečujejo učitelji. Glede na analizo smo razvili prototip aplikacije, ki je prilagojen za podpor ...
Leto:
2024
Vir:
Fakulteta za informacijske študije v Novem mestu (FIŠ)
Izvirni znanstveni članek
Oznake:
molecular design;molecular simulations;deep learning;human DNA;topoisomerase IIα;catalytic inhibitors;anticancer agents;
The 4,6-substituted-1,3,5-triazin-2(1H)-ones are promising inhibitors of human DNA topoisomerase IIα. To further develop this chemical class targeting the enzyme´s ATP binding site, the triazin-2(1H)-one substitution position 6 was optimized. Inspired by binding of preclinical substituted 9H-purine ...
Leto:
2024
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
Tollu podoben receptor 8;antagonisti TLR8;izoksazol;
Toll-like receptor 8 (TLR8) recognizes viral and bacterial RNA, initiating inflammatory responses that are crucial for innate immunity. Dysregulated TLR8 signaling contributes to autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis, driving chronic inflammation and ti ...
Leto:
2025
Vir:
Fakulteta za farmacijo (UL FFA)
Eva Ružić-Sabljić,
Daša Podgoršek,
Katja Strašek,
Andraž Celar Šturm,
Mateja Logar,
Andrea Pavlović,
Tatjana Remec-Zafred,
Zvonko Baklan,
Emil Pal,
Tjaša Cerar,
Tjaša Cerar
Izvirni znanstveni članek
Oznake:
Leptospira sp.;leptospirosis;Slovenia;1fb gene;MALDI-TOF;NotI-RFLP;MLST;WGS;
Leptospirosis is an important worldwide zoonosis, and it has also been reported in Slovenia. The cultivation of Leptospira from human material is difficult. Despite that, we successfully isolated 12 human Leptospira strains isolated from patients between 2002 and 2020 and used various methods for th ...
Leto:
2023
Vir:
Digitalna knjižnica Univerze v Mariboru (DKUM)
Izvirni znanstveni članek
Oznake:
MALDI-TOF MS;OmniLog ID System;microbial identification;metagenomics;speleotherapy;cave aerobiology;nitrocellulose filters;
The effective identification of bacterial and fungal isolates is essential for microbiological monitoring in environments like speleotherapeutic caves. This study compares MALDI-TOF MS and the OmniLog ID System, two high-throughput culture-based identification methods. MALDI-TOF MS identified 80.0% ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)
Nika Strašek,
David Lukić,
Tjaša Slokan,
Ana Dolšak,
Urban Švajger,
Simona Kranjc,
Valerij Talagayev,
Gerhard Wolber,
Maja Čemažar,
Izidor Sosič,
Matej Sova
Izvirni znanstveni članek
Oznake:
Tollu podobni receptorji;TLR7;TLR8;agonist;molekula majhne velikosti;sinteza;kinazolin;Toll-like receptor;Small-molecule;synthesis;quinazolinone;
Toll-like receptors (TLRs) 7 and 8 are intracellular pattern recognition receptors that play a crucial role in the innate immune system, making them promising targets for the treatment of viral infections, autoimmune diseases and cancer. In this study, we present the synthesis and biological evaluat ...
Leto:
2026
Vir:
Fakulteta za farmacijo (UL FFA)
Troy Matziol,
Valerij Talagayev,
Nika Strašek,
Felicitas Lauber,
Paula von Kempis,
Tjaša Slokan,
Janine Holze,
Erika Kulitzki,
Günther Weindl,
Günther Weindl,
Matej Sova,
Matej Sova
Izvirni znanstveni članek
Oznake:
Toll-like receptors;TLR8;anti-inflammatory;drug discovery;pyrimidine;quinazoline;antagonists;
Toll-like receptor 8 (TLR8) plays a key role in inflammatory and autoimmune disease pathogenesis. The development of TLR8 antagonists has therefore increased in recent years, however, no clinical candidates have yet reached the market. Here, we report a novel chemotype of selective TLR8 antagonists ...
Leto:
2026
Vir:
Fakulteta za farmacijo (UL FFA)
Kratki znanstveni prispevek
Oznake:
Mycoplasma arginini;Slovenia;arthritis;bacteria;cellulitis;immunocompromised;kidney transplant recipient;zoonoses;
Mycoplasma arginini is a bacterium primarily found in animals and is seldom reported in human infections. We identified M. arginini infection in a severely immunocompromised kidney transplant recipient in Slovenia. Clinicians should be aware of M. arginini's potential as a pathogen in immunocompromi ...
Leto:
2025
Vir:
Medicinska fakulteta (UL MF)