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Št. zadetkov: 9
Implementacija PLOR modela in QFD matrike v proces razvoja ročno narejenih izdelkov iz filca
Tina Kristina Trobec, Matjaž Roblek
Diplomsko delo
Oznake: izdelek;filc;metoda razvoja funkcij kakovosti (QFD);
V diplomskem delu smo se lotili problema prodora na trg z ročno izdelanimi izdelki iz filca. S pomočjo raziskave trga smo želeli ugotoviti, kateri izdelek, narejen iz filca, bi bil najbolj zanimiv za potencialnega kupca. Idejni izdelek in njegove tehnične značilnosti smo razvili s pomočjo metode raz ...
Leto: 2016 Vir: Fakulteta za organizacijske vede (UM FOV)
Novel organoruthenium(II) complex C1 selectively inhibits butyrylcholinesterase without side effects on neuromuscular transmission
Tomaž Trobec, Monika C. Žužek, Kristina Sepčić, Jerneja Kladnik, Iztok Turel, Robert Frangež
Izvirni znanstveni članek
Oznake: organoruthenium(II) complex;acetylcholinesterase;butyrylcholinesterase;mouse neuromuscular system;ruthenium;Alzheimer disease;neurodegenerative diseases;
Enzyme butyrylcholinesterase (BChE) shows increased activity in some brain regions after progression of Alzheimer’s disease and is therefore one of the therapeutic targets for symptomatic treatment of this neurodegenerative disorder. The organoruthenium(II) complex [(n6-pcymene) Ru(II)(1-hydroxy-3-m ...
Leto: 2023 Vir: Veterinarska fakulteta (UL VF)
Structural and functional characterization of an organometallic ruthenium complex as a potential myorelaxant drug
Tomaž Trobec, Monika C. Žužek, Kristina Sepčić, Jerneja Kladnik, Jakob Kljun, Iztok Turel, Evelyne Benoit, Robert Frangež
Izvirni znanstveni članek
Oznake: organoruthenium nitrophenanthroline complex;acetylcholinesterase;butyrylcholinesterase;glutathione S-transferase;mouse neuromuscular system;ruthenium;muscle relaxation;physiology;glutathione transferase;
In addition to antibacterial and antitumor effects, synthetic ruthenium complexes have been reported to inhibit several medicinally important enzymes, including acetylcholinesterase (AChE). They may also interact with muscle-type nicotinic acetylcholine receptors (nAChRs) and thus affect the neuromu ...
Leto: 2020 Vir: Veterinarska fakulteta (UL VF)
Development of potent cholinesterase inhibitors based on a marine pharmacophore
Vijayaragavan Elumalai, Tomaž Trobec, Maja Grundner, Christophe Labriere, Robert Frangež, Kristina Sepčić, Jørn H. Hansen, Johan Svenson
Izvirni znanstveni članek
Oznake: Nervous System Diseases;Cholinesterase Inhibitors;
The management of neurological disorders such as dementia associated with Alzheimer’s or Parkinson’s disease includes the use of cholinesterase inhibitors. These compounds can slow down the progression of these diseases and can also be used in the treatment of glaucoma and myasthenia gravis. The m ...
Leto: 2022 Vir: Veterinarska fakulteta (UL VF)
Using virtual AChE homology screening to identify small molecules with the ability to inhibit marine biofouling
Homayon John Arabshahi, Tomaž Trobec, Valentin Foulon, Claire Hellio, Robert Frangež, Kristina Sepčić, Patrick Cahill, Johan Svenson
Izvirni znanstveni članek
Oznake: homology screening;in silico screening;in vitro enzymatic studies;cholinesterase;AChE inhibitor;antifouling;
The search for effective yet environmentally friendly strategies to prevent marine biofouling is hampered by the large taxonomic diversity amongst fouling organisms and a lack of well-defined conserved molecular targets. The acetylcholinesterase enzyme catalyses the breakdown of the neurotransmit ...
Leto: 2021 Vir: Veterinarska fakulteta (UL VF)
Fine tuning of cholinesterase and glutathione-S-transferase activities by organoruthenium(II) complexes
Tomaž Trobec, Kristina Sepčić, Monika C. Žužek, Jerneja Kladnik, Nina Podjed, Catarina Cardoso Páscoa, Iztok Turel, Robert Frangež
Izvirni znanstveni članek
Oznake: cholinesterase;enzyme inhibition;glutathione S-transferase;organoruthenium complex;pyrithione;β-diketone;carbonyl;glutathione transferase;
Cholinesterases (ChEs) show increased activities in patients with Alzheimer’s disease, and remain one of the main therapeutic targets for treatment of this neurodegenerative disorder. A library of organoruthenium(II) complexes was prepared to investigate the influence of their structural elements on ...
Leto: 2021 Vir: Veterinarska fakulteta (UL VF)
Effects of bioinsecticidal aegerolysin-based cytolytic complexes on non-target organisms
Anastasija Panevska, Gordana Glavan, Anita Jemec, Veronika Kukuljan, Tomaž Trobec, Monika C. Žužek, Milka Vrecl, Damjana Drobne, Robert Frangež, Kristina Sepčić
Izvirni znanstveni članek
Oznake: stranski učinki;egerolizini;Apis mellifera;bioinsekticidi;erilizin A;protein z domeno MACPF;netarčni organizmi;bukov ostrigar;Porcellio scaber;toksičnost;adverse effects;aegerolysins;bioinsecticides;erylysin A;MACPF protein;non-target organisms;oyster mushroom;toxicity;
Aegerolysin proteins ostreolysin A6 (OlyA6), pleurotolysin A2 (PlyA2) and erylysin A (EryA) produced by the mushroom genus Pleurotus bind strongly to an invertebrate-specific membrane sphingolipid, and together with a protein partner pleurotolysin B (PlyB), form transmembrane pore complexes. This po ...
Leto: 2021 Vir: Biotehniška fakulteta (UL BF)
Spatial distribution and stability of cholinesterase inhibitory protoberberine alkaloids from Papaver setiferum
Ulf Göransson, Lindon W. K. Moodie, Luke P. Robertson, Neda Safa, Tomaž Trobec, Darren C. Holland, Blazej Slazak, Erik Jacobsson, Jeffrey A. Hawkes, Robert Frangež, Kristina Sepčić
Izvirni znanstveni članek
Oznake: Cholinesterase Inhibitors;Papaver;Alkaloids;
During a research program to identify new cholinesterase inhibitors of natural origin, two new 7,8-didehydroprotoberberine alkaloids (1 and 2) and nine known compounds (3−11) were isolated from the capsules of the common ornamental poppy, Papaver setiferum (previously P. pseudo-orientale). Despite t ...
Leto: 2022 Vir: Veterinarska fakulteta (UL VF)
Revealing subtle active tectonic deformation: integrating lidar, photogrammetry, field mapping, and geophysical surveys to assess the Late Quaternary activity of the Sava Fault (Southern Alps, Slovenia)
Petra Jamšek Rupnik, Jure Atanackov, Barbara Horn, Branko Mušič, Marjana Zajc, Christoph Grützner, Kamil Ustaszewski, Sumiko Tsukamoto, Matevž Novak, Blaž Milanič, Anže Markelj, Kristina Ivančič, Ana Trobec, Jernej Jež, Manja Žebre, Miloš Bavec, Marko Vrabec
Izvirni znanstveni članek
Oznake: tektonika;strukturna geologija;daljinsko zaznavanje;geofizikalne meritve;Savski prelom;Južne Alpe;
We applied an interdisciplinary approach to analyze the late Quaternary activity of the Sava Fault in the Slovenian Southern Alps. The Sava Fault is an active strike-slip fault, and part of the Periadriatic Fault System that accommodated the convergence of Adria and Europe. It is one of the longest ...
Leto: 2024 Vir: Geološki zavod Slovenije (GeoZS)
Št. zadetkov: 9
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