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Št. zadetkov: 8
Optimizacija procesov in formulacij pri 3D tiskanju tablet
Klemen Kreft, Rok Dreu
Doktorska disertacija
Oznake: 3D tiskanje;personalizirana zdravila;tehnologija ciljnega nalaganja;praškovno brizgalna tehnologija;bolniku prilagojen odmerek;razvoj formulacij in procesa.;
Farmacevtska skupnost je zaradi potreb po bolj personaliziranem zdravljenju primorana razvijati nove načine za pripravo zdravil. 3D tiskanje je ena izmed potencialnih tehnologij, ki omogoča izdelavo trdnih farmacevtskih oblik s prilagojenim odmerkom. Kljub odobritvi prvega 3D tiskanega zdravila s s ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Vrednotenje vpliva simulacije luminalnih pogojev želodca na gelsko plast ogrodnih tablet
Klemen Kreft, Jurij Trontelj, Igor Legen
Magistrsko delo
Oznake: naprava za posnemanje želodčnega gibanja;naprava za vrednotenje teksture;hidrofilne ogrodne tablete;mehanska obremenitev;pH gradient;
Posnemanje in vivo pogojev z metodami in vitro omogoča različno dobro približanje fiziološkim pogojem. Znana je biorelevantna naprava za posnemanje želodčnega gibanja, ki so jo razvili v podjetju Lek d.d. v Ljubljani v sodelovanju s Fakulteto za strojništvo iz Univerze v Ljubljani. Naprava za posnem ...
Leto: 2019 Vir: Fakulteta za farmacijo (UL FFA)
Influence of the binder jetting process parameters and binder liquid composition on the relevant attributes of 3D-printed tablets
Klemen Kreft, Zoran Lavrič, T. Stanić Ljubin, Petra Perhavec, Rok Dreu
Izvirni znanstveni članek
Oznake: brizganje veziva;načrtovanje poskusov;3D-natisnjene tablice;mehanske lastnosti;razvoj tiskalnikov;ketoprofen;binder jetting;design of experiments;3D-printed tablets;mechanical properties;printer development;
Binder jetting has the potential to revolutionize the way we produce medicine. However, tablets produced by binder jetting technology can be quite fragile and hard to handle. In this study, the printing process and ink composition were examined to optimize the mechanical properties of tablets. A mod ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Influence of fused deposition modelling printing parameters on tablet disintegration times
Klemen Kreft, T. Stanić Ljubin, Petra Perhavec, Rok Dreu, Zoran Lavrič
Izvirni znanstveni članek
Oznake: 3D tiskane tablete;razpadni čas;modeliranje taljenega nanosa;zasnova eksperimentov;parametri tiskanja;enakomernost mase;
Despite the importance of process parameters in the printing of solid dosage forms using fused deposition modelling (FDM) technology, the field is still poorly explored. A design of experiment study was conducted to understand the complete set of process parameters of a custom developed FDM 3D print ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Correlating mechanical and rheological filament properties to processability and quality of 3D printed tablets using multiple linear regression
Klemen Kreft, Zoran Lavrič, Urška Gradišar Centa, Mohor Mihelčič, Lidija Slemenik Perše, Rok Dreu
Izvirni znanstveni članek
Oznake: fused deposition modelling;personalized medicine;multiple linear regression;tablet quality attributes;correlation;3D printing;
Filament formulation for FDM is a challenging and time-consuming process. Several pharmaceutical polymers are not feedable on their own. Due to inadequate filament formulation, 3D printed tablets can also exhibit poor uniformity of tablet attributes. To better understand filament formulation process ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Proposing urothelial and muscle in vitro cell models as a novel approach for assessment of long-term toxicity of nanoparticles
Matej Skočaj, Maruša Rajh, Klemen Strojan, Jasna Lojk, Mateja Erdani-Kreft, Katarina Miš, Sergej Pirkmajer, Vladimir Boštjan Bregar, Peter Veranič, Mojca Pavlin
Izvirni znanstveni članek
Oznake: nanotoksikologija;in vitro L6 mišična celična linija;urotelij;diferenciacija;celična signalizacija;ROS;nanotoxicology;in vitro L6 rat skeletal muscle cell line;urothelium in vitro;differentiation;cell signaling;
Many studies evaluated the short-term in vitro toxicity of nanoparticles (NPs); however, long-term effects are still not adequately understood. Here, we investigated the potential toxic effects of biomedical (polyacrylic acid and polyethylenimine coated magnetic NPs) and two industrial (SiO$_2$ and ...
Leto: 2020 Vir: Fakulteta za elektrotehniko (UL FE)
Cabbage and fermented vegetables
Jean Bousquet, Josep M. Antò i Boquè, Wienczyslawa Czarlewski, Tari Haahtela, Susana C. Fonseca, Guido Laccarino, Hubert Blain, Alain Vidal, Aziz Sheikh, Cezmi A. Akdis, Torsten Zuberbier, Samo Kreft, Klemen Jenko, Maja Jošt, Peter Kopač, Mitja Košnik, Karmen Kramer Vrščaj, Bojan Madjar, Davor Plavec, Tanja Soklič, Jure Urbančič, Mihaela Zidarn
Pregledni znanstveni članek
Oznake: koronavirus;fermentirana zelenjava;kimči;COVID-19;diet;sulforaphane;Lactobacillus;Angiotensin converting enzyme 2;kimchi;cabbage;fermented vegetable;
Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ...
Leto: 2021 Vir: Repozitorij Univerze v Ljubljani (RUL)
Is diet partly responsible for differences in COVID-19 death rates between and within countries?
Jean Bousquet, Josep M. Antò i Boquè, Guido Laccarino, Wienczyslawa Czarlewski, Tari Haahtela, Aram Anto, Cezmi A. Akdis, Hubert Blain, Giorgio Walter Canonica, Karmen Kramer Vrščaj, Tari Haahtela, Mitja Košnik, Anja Koren, Peter Kopač, Maja Jošt, Samo Kreft, Klemen Jenko, Bojan Madjar, Davor Plavec, Tanja Soklič, Jure Urbančič, Mihaela Zidarn
Pregledni znanstveni članek
Oznake: coronavirus;diet;angiotensin-converting enzyme;antioxidant;food;
Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has be ...
Leto: 2020 Vir: Repozitorij Univerze v Ljubljani (RUL)
Št. zadetkov: 8
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